Experiment 676210
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Camellia sinensis (THEACEAE) |
| Citation | BROWN,MD:. (1999). GREEN TEA (CAMELLIA SINENSIS) EXTRACT AND ITS POSSIBLE ROLE IN THE PREVENTION OF CANCER.. 4(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | THERE IS SOME EVIDENCE TO SUGGEST GREEN TEA POLYPHENOSL (GTP) HAVE A CHEMOPREVENTIVE EFFECT IN SMOKERS AND THE INCIDENE OF LUNG CANCER. THE CHEMOPREVENTIVE EFFECTS OF GREEN TEA AND COFFEE AMONG CIGARETTE SMOKERS WERE EXAMINED IN 52 CLINICALLY HEALTHY MALE SUBJECTS BETWEEN AGES 20-51. SUBJECTS WERE DIVIDED INTO FOUR GROUPS: NON-SMOKERS (GROUP 1), SMOKERS (II), SMOKERS CONSUMING GREEN TEA (III), AND SMOKERS/COFFEE DRINKERS (IV). THE MEAN YEARS OF SMOKING (>10 CIGARETTES/DAY) OF GROUPS II, III, IV, RANGED FROM 13.4-14.7 YEARS. THE VOLUNTEERS DAILY INTAKE OF GREEN TEA AND COFFEE(GROUPS II AND IV) WAS THREE CUPS PER DAY OVER SIX MONTHS. THE FREQUENCIES OF SISTER-CHROMATID EXCHANGE (SCE) IN MITOGEN-STIMULATED PERIPHERAL LYMPHOCYTES FROM EACH EXPERIMENTAL GROUP WERE DETERMINED AND STATISTICALLY ANALYZED. SCE RATES WERE SIGNIFICANTLY ELEVATED IN SMOKERS (0.46+/-0.46) VS. NON-SMOKERS (7.03+/-0.33); HOWEVER, THE FREQUENCY OF SCE IN SMOKERS WHO CONSUMED GREEN TEA WAS COMPARABLE TO NON-SMOKERS (7.94+/0.31) =, SUGGESTING GTP MAY HAVE AN ANTIMUTAGENIC EFFECT AGAINST SMOKE-INDUCED MUTATIONS IN HUMANS BY BLOCKING THE CIGARETTE-INDUCED INCREASE IN SCE FREQUENCY. |
| Number | 9 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | INFUSION |
| Gender | GIVEN TO BOTH SEXES |