Experiment 67626
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | EXTERNAL |
| Organism | Empty organism |
| Citation | GRIMAITRE,M: ETIENNE,A: FATHI,M: PILETTA,PA: SAURAT,JH:. (2000). TOPICAL COLCHICINE THERAPY FOR ACTINIC KERATOSES.. (9) |
| Amount utilized | |
| Compound isolated | |
| Disease | TO CONFIRM THAT THE APPLICATION OF A 1% COLCHICINE GEL IS A SAFE AND EFFECTIVE TREATMENT FOR ACTINIC KERATOSES, TWENTY PATIENTS WERE INCLUDED IN A DOUBLE-BLINDED PROTOCOL. THEY ALL HAD ACTINIC KERATOSES ON THE SCALP. TEN PATIENTS APPLIED TWICE DAILY ON THE FOREHEAD A HYDROPHILIC GEL (PLACEBO GROUP), WHILE THE OTHER 10 WERE TREATED WITH THE SAME GEL CONTG. 1% OF COLCHICINE (COLCHINCINE GROUP). ERYTHEMA AND EFFICACY WERE EVALUATED AT EACH CONTROL ON DAYS 7,30 AND 60, WITH REPETITIVE BLOOD TESTS TO EXCLUDE A POSSIBLE SYSTEMIC ABSORPTION. RESULTS: A COMPLETE HEALING OF THE SOLAR KERATOSES WAS OBSD. IN 7 OUT OF THE 10 PATIENTS TREATED WITH 1% COLCHICINE GEL; THESE SHOWED NO RECURRENCE AFTER 2 MO OF FOLLOW-UP. BURNING AND ITCHING OCCURRED ONLY IN THE COLCHINCINE GROUP AFTER 2 OR 3 DAYS OF APPLICATION, WITH AN INFLAMMATORY REACTION ON THE AREAS WHERE THE GEL WAS APPLIED, WHILE PUSTULES AND CRUSTS WERE LOCATED SPECIFICALLY ON THE ACTINIC KERATOSES. |
| Dose amount | 1.0% |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | CONC USED |