Experiment 67638
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | DE ROOS,B: CASLAKE,MJ: STALENHOEF,AFH: BEDFORD,D: DEMACKER,PNM: KATAN,MB: PACKARD,CJ:. (2001). THE COFFEE DITERPENE CAFESTOL INCREASES PLASMA TRIACYLGLYCEROL BY INCREASING THE PRODUCTION RATE OF LARGE VLDL APOLIPOPROTEIN B IN HEALTHY NORMOLIPIDEMIC SUBJECTS.. 73(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | EIGHT HEALTHY NORMOLIPIDEMIC MEN WERE ADMINISTERED A DAILY DOSE OF 75 MG CAFESTOL FOR 2 WK. A BOLUS INJECTION OF 7 MG L-[5,5,5-2H3]LEUCINE/KG BODY WT WAS GIVEN AFTER A BASELINE PERIOD WITH NO CAFESTOL AND AGAIN AFTER TREATMENT WITH CAFESTOL. WE DERIVED KINETIC CONSTANTS TO DESCRIBE THE METABOLISM OF VLDL1 APO B BY USING A MULTICOMPARTMENTAL MODE. CAFESTOL SIGNIFICANTLY INCREASED PLASMA TRIACYLGLYCEROL BY 31% CAFESTOL SIGNIFICANTLY INCREASED THE MEAN RATE OF VLDL1 APO B PRODUCTION BY 80%. |
| Dose amount | 75.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Gender | MALE |