| Disease | FOLLOWING 49H OF PROLONGED WAKEFULNESS, EACH OF 50 HEALTHY MALES ORALLY INGESTED EITHER A PLACEBO OR ONE OF THREE DOSES OF CAFFEINE, 2.1 (LOW), 4.3(MEDIUM), OR 8.6 MG KG-1 BODY WEIGHT (HIGH), IN A RANDOMIZED DOUBLE-BLIND DESIGN. WAKEFULNESS
CONTINUED FOR AN ADDITIONAL 12H DURING WHICH VENOUS BLOOD SAMPLES WERE COLLECTED FOR CATECHOLAMINE AND CAFFEINE ANALYSIS. A SLEEP LATENCY TEST, THE STANFORD SLEEPINESS SCALE, AND A CHOICE REACTION TIME TEST WERE ADMINISTERED AS MEASURES OF
ALERTNESS. CAFFEINE HAD NO SIGNIFICANT EFFECT ON NORADRENALINE, BUT ADRENALINE WAS SIGNIFICANTLY INCREASED BETWEEN 1H AND 4H POST-DOSING IN THE HIGH DOSE GROUP COMPARED WITH A PLACEBO GROUP. FOLLOWING CAFFEINE ADMINISTRATION, RESPONSES TO SLEEP
LATENCY, SLEEPINESS SCORES, AND REACTION TIME SCORES SHOWED DOSE-RELATED CHANGES THAT WERE EXHIBITED BY SIGNIFICANT CORRELATION COEFFICIENTS. |