Experiment 67652
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | SCHEMPP,CM: MULLER,K: WINGHOFER,B: SCHULTE MONTING,J: SIMON,JC:. (2001). SINGLE-DOSE AND STEADY-STATE ADMINISTRATION OF HYPERICUM PERFORATUM EXTRACT (ST JOHN'S WORT) DOES NOT INFLUENCE SKIN SENSITIVITY TO UV RADIATION, VISIBLE LIGHT, AND SOLAR-SIMULATED RADIATION.. 137(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | SEVENTY-TWO HEALTHY VOLUNTEERS WERE INCLUDED IN THE STUDY. IN THE SINGLE-DOSE TRIAL, THE VOLUNTEERS (N=48) RECEIVED 6 OR 12 COATED TABLETS OF THE HYPERICUM EXTRACT LI 160 (CONTAINING 5400 OR 10800 MCG OF TOTAL HYPERICINS). IN THE STEADY-STATE TRIAL, THE VOLUNTEERS (N=24) RECEIVED AN INITIAL DOSE OF 6 TABLETS (1800 MCG OF HYPERICINS), AND SUBSEQUENTLY 3 X 1 TABLETS (2700 MCG OF HYPERICINS) PER DAY FOR 7 DAYS. PHOTOTESTING WAS PERFORMED ON THE VOLAR FOREARMS PRIOR TO AND 6 HOURS AFTER THE LAST ADMINISTRATION OF HYPERICUM EXTRACT. AFTER BOTH SINGLE-DOSE AND MULTIPLE DOSES OF THIS PREPARATION, NO SIGNIFICANT CHANGES IN ERYTHEMA THRESHOLD LEVELS COULD BE DETECTED. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |