Experiment 67659
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Theobroma cacao (STERCULIACEAE) |
| Citation | SCHRAMM,DD: WANG,JF: HOLT,RR: ENSUNSA,JL: GONSALVES,JL: LAZARUS,SA: SCHMITZ,HH: GERMAN,JB: KEEN,CL:. (2001). CHOCOLATE PROCYANIDINS DECREASE THE LEUKOTRIENE-PROSTACYCLIN RATIO IN HUMANS AND HUMAN AORTIC ENDOTHELIAL CELLS.. 73(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | AFTER AN OVERNIGHT FAST, 10 HEALTHY SUBJECTS CONSUMED 37 G LOW-PROCYANIDIN (0.09 MG/G) AND HIGH-PROCYANIDIN (4.0 MG/G) CHOCOLATE; THE TREATMENTS WERE SEPARATED BY 1 WK. THE INVESTIGATION HAD A RANDOMIZED, BLINDED, CROSSOVER DESIGN. PLASMA SAMPLES WERE COLLECTED BEFORE TREATMENT AND 2 AND 6H AFTER TREATMENT. EICOSANOIDS WERE QUANTITATED BY ENZYME IMMUNOASSAY. RELATIVE TO THE EFFECTS OF THE LOW-PROCYANIDIN CHOCOLATE, HIGH-PROCYANIDIN CHOCOLATE INDUCED INCREASES IN PLASMA PROSTACYCLIN AND DECREASES IN PLASMA LEUKOTRIENES. |
| Dose amount | 4.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | GM |
| Dose expression | DOSE |
| Extract | PROCYANIDIN FRACTION |
| Gender | GIVEN TO BOTH SEXES |