Experiment 67704
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | KANAZAWA,S: OHKUBO,T: SUGAWARA,K:. (2001). THE EFFECTS OF GRAPEFRUIT JUICE ON THE PHARMACOKINETICS OF ERYTHROMYCIN.. 56(11) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE EFFECTS OF GRAPEFRUIT JUICE INTAKE ON THE PHARMACOKINETICS OF ERYTHROMYCIN WERE INVESTIGATED IN SIX HEALTHY MALE VOLUNTEERS. THE STUDY HAD AN OPENCROSSOVER DESIGN AFTER A 4-WEEK WASHOUT PERIOD. THE SUBJECTS WERE PRETREATED WITH EITHER 300 ML OF WATER OR GRAPEFRUIT JUICE 30 MIN BEFORE THE ORAL ADMINISTRATION OF 400 MG ERYTHROMYCIN. GRAPEFRUIT JUICE, COMPARED WITH WATER INTAKE, SIGNIFICANTLY (P<0.05) INCREASED THE MEAN CMAX VALUE AND THE MEAN AUC 0-12 VALUE OF ERYTHROMYCIN. HOWEVER, THE TMAX AND 1 1/2 VALUES OF ERYTHROMYCIN WERE NOT AFFECTED BY GRAPEFRUIT JUICE INTAKE. |
| Dose amount | 300.0 ML |
| Number | 1 |
| Qualitative result | . |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | JUICE |
| Gender | MALE |