Experiment 67717
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | OLTHOF,MR: HOLLMAN,PC: XOCK,PL: KATAN,MB:. (2001). CONSUMPTION OF HIGH DOSES OF CHLOROGENIC ACID, PRESENT IN COFFEE, OR BLACK TEA INCREASES PLASMA TOTAL HOMOCYSTEINE CONCENTRATIONS IN HUMANS.. 73(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS CROSSOVER STUDY, 20 HEALTHY MEN AND WOMEN INGESTED 2 G (5.5 MMOL) CHLOROGENIC ACID, 4 G BLACK TEA SOLIDS CONTAINING 4.3 MMOL POLYPHENOLS AND COMPARABLE TO 2 L STRONG BLACK TEA, 440 MG (0.7 MMOL) QUERCETIN-3-RUTINOSIDE, OR A PLACEBO DAILY EACH SUBJECT RECEIVED EACH OF THE 4 TREATMENTS FOR 7D, IN RANDOM ORDER. TOTAL HOMOCYSTEINE IN PLASMA COLLECTED 4-5H AFTER SUPPLEMENT INTAKE WAS 12% HIGHER AFTER CHLOROGENIC ACID AND 11% HIGHER AFTER BLACK TEA THAN AFTER PLACEBO. QUERCETIN-3-RUTINOSIDE DID NOT SIGNIFICANTLY AFFECT HOMOCYSTEINE CONCENTRATIONS. |
| Dose amount | 2.0 GM |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | PERSON |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |