Experiment 67725
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | MALHOTRA,S: BAILEY,DG: PAINE,MF: WATKINS,PB:. (2001). SEVILLE ORANGE JUICE-FELODIPINE INTERACTION: COMPARISON WITH DILUTE GRAPEFRUIT JUCIE AND INVOLVEMENT OF FUROCOUMARINS.. 69(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN A RANDOMIZED THREE-WAY CROSSOVER DESIGN, 10 VOLUNTEERS RECEIVED A FELODIPINE 10-MG EXTENDED-RELEASE TABLET WITH 240 ML OF SEVILLE ORANGE JUICE, DILUTE GRAPEFRUIT JUICE OR COMMON ORANGE JUICE. THE PHARMACOKINETICS OF FELODIPINE AND ITS DEHYDROFELODIPINE METABOLITE WERE DETERMINED. JUICE CONCENTRATIONS OF FUROCOUMARINS WERE MEASURED. CYP3A4 INHIBITORY ACTIVITY OF NEWLY IDENTIFIED FUROCOUMARINS WAS ASSESSED. THE FELODIPINE AREA UNDER THE PLASMA CONCENTRATION-TIME CURVE WAS INCREASED BY 76% AND 93% AFTER SEVILLE ORANGE JUICE AND GRAPEFRUIT JUICE INGESTION, RESPECTIVELY, COMPARED WITH COMMON ORANGE JUICE. |
| Dose amount | 240.0 ML |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | JUICE |
| Gender | GIVEN TO BOTH SEXES |