Experiment 67744
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | BAILEY,DG: DRESSER,K: KREEFT,JH: MUNOZ,C: FREEMAN,DJ: BEND,JR:. (2000). GRAPEFRUIT-FELODIPINE INTERACTION: EFFECT OF UNPROCESSED FRUIT AND PROBABLE ACTIVE INGREDIENTS.. 68(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE ORAL PHARMACOKINETICS OF FELODIPINE AND ITS DEHYDROFELODIPINE METABOLITE WERE DETERMINED AFTER ADMINISTRATION OF FELODIPINE 10 MG EXTENDED-RELEASE TABLET WITH 250 ML COMMERCIAL GRAPEFRUIT JUICE, HOMOGENIZED GRAPEFRUIT SEGMENTS, OR EXTRACT OF SEGMENT-FREE PARTS EQUIVALENT TO ONE UNPROCESSED FRUIT OR WATER IN A RANDOMIZED FOUR-WAY CROSSOVER STUDY. INHIBITION OF RECOMBINANT CYP3A4 BY FURANOCOUMARINS WAS DETERMINED. FELODIPINE AUC WITH COMMERCIAL GRAPEFRUIT JUICE, GRAPEFRUIT SEGMENTS, OR GRAPEFRUIT EXTRACT WAS ON AVERAGE 3-FOLD HIGHER THAN THAT WITH WATER. THE FURANOCOUMARINS PRODUCED MECHANISM-BASED AND COMPETITIVE INHIBITION OF CYP3A4. |
| Dose amount | 250.0 ML |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | FRUIT |
| Gender | GIVEN TO BOTH SEXES |