Experiment 67831
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Salix daphnoides (SALICACEAE) |
| Citation | KRIVOY,N: PAVLOTZKY,E: CHRUBASIK,S: EISENBERG,E: BROOK,G:. (2001). EFFECT OF SALICIS CORTEX EXTRACT ON HUMAN PLATELET AGGREGATION.. 67(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE AIM OF THIS STUDY WAS TO INVESTIGATE IF DURING PAIN TREATMENT WITH SALICIS CORTEX EXTRACT PLATELET AGGREGATION WAS AFFECTED. A TOTAL OF 51 PATIENTS WERE ENROLLED IN THE STUDY. THIRTY-FIVE PATIENTS SUFFERING FROM ACUTE EXACERBATIONS OF CHRONIC LOW BACK PAIN RECEIVED RANDOMLY AND DOUBLE-BLIND EITHER SALICIS CORTEX EXTRACT WITH 240 MG SALICIN/DAY (N=19) OR PLACEBO (N=16). PLATELET AGGREGATION WAS STUDIED USING AN AGGREGOMETER. THE MEAN MAXIMAL ARACHIDONIC ACID INDUCED PLATELET AGGREGATION WAS 61%, 78% AND 13% IN THE SALICIS CORTEX EXTRACT, PLACEBO AND ACETYLSALICYLATE GROUPS.ACETYLSALICYLATE HAD A SIGNIFICANT INHIBITORY EFFECT ON PLATELET AGGREGATION COMPARED TO SALICIS CORTEX EXTRACT (P=0.001) AND PLACEBO (P=0.001). THERE WAS ALSO A SIGNNIFICANT DIFFERENCE BETWEEN THE PLACEBO AND THE WILLOW BARK-TREATED GROUPS IN THE MAXIMAL PLATELET AGGREGATION INDUCED BY ARACHIDONIC ACID (P=0.04) AND ADP (P=0.01). NO STATISTICAL DIFFERENCE WAS FOUND BETWEEN THE GROUPS WHEN COLLAGEN WAS APPLIED TO THE HUMAN PLATELETS. |
| Dose amount | 240.0 MG |
| Number | 2 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | ETOH(70%)EXT |
| Gender | GIVEN TO BOTH SEXES |