Experiment 67858
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | SINDRUP,SH: MADSEN,C: BACH,FW: GRAM,LF: JENSEN,TS:. (2000). ST. JOHN'S WORT HAS NO EFFECT ON PAIN IN POLYNEUROPATHY.. 91(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE STUDY DESIGN WAS RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED AND CROSS-OVER. FIFTY-FOUR PATIENTS WERE ASSIGNED TO ONE OF THE TWO TREATMENT SEQUENCES. THE DAILY DOSE OF ST. JOHN'S WORT WAS THREE TABLETS EACH CONTAINING 900 MG TOTALHYPERICIN. DURING THE TWO TREATMENT PERIODS OF 5 WEEKS DURATION, PATIENTS RATED CONSTANT PAIN, LANCINATING PAINPAROXYSMS; TOUCH-EVOKED PAIN AND PAIN ON PRESSURE BY USE OF 0-10 POINT NUMERIC RATING SCALES. FORTY-SEVEN PATIENTS-18 DIABETICS AND 29 NON- DIABETICS-COMPLETED THE STUDY. THERE WAS A TREND OF LOWER TOTAL PAIN SCORE ON ST. JOHN'S WORT THAN ON PLACEBO (MEDIAN 14 VS. 15, P=0.05). NONE OF THE INDIVIDUAL PAIN RATINGS WERE SIGNIFICANTLY CHANGED BY ST. JOHN'S WORT AS COMPARED TO PLACEBO (P=0.09-0.33). CALMIGEN TABLETS WERE USED IN THE STUDY. A COMMERCIAL PRODUCT, CALMIGEN, WAS USED. |
| Dose amount | 900.0 MCG |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | TYPE EXT NOT STATED |
| Gender | GIVEN TO BOTH SEXES |