Experiment 67859
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Serenoa repens (ARECACEAE) |
| Citation | MARKS,LS: HESS,DL: DOREY,FJ: MACAIRAN,ML: BRYAN,P: SANTOS,C: TYLER,VE:. (2001). TISSUE EFFECTS OF SAW PALMETTO AND FINASTERIDE: USE OF BIOPSY CORES FOR IN SITU QUANTIFICATION OF PROSTATIC ANDROGENS.. 57(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | PROSTATE LEVELS OF TESTOSTERONE AND DIHYDROTESTOSTERONE (DHT) WERE MEASURED ON 5 TO 10-MG BIOPSY SPECIMENS IN THREE GROUPS OF MEN WITH SYMPTOMATIC BENIGN PROSTATIC HYPERPLASIA: 15 MEN RECEIVING CHRONIC FINASTERIDE THERAPY VERSUS 7 UNTREATED CONTROLS; 4 MEN UNDERGOING PROSTATE ADENOMECTOMY TO DETERMINE SAMPLING VARIABILITY AND 40 MEN PARTICIPATING IN A 6-MONTH RANDOMIZED TRIAL OF SPHB VERSUS PLACEBO, BEFORE AND AFTER TREATMENT. PROSTATIC TISSUE DHT LEVELS WERE FOUND TO BE SEVERAL TIMES HIGHER THAN THE LEVELS OF TESTOSTERONE THAT RATIO BECOMING REVERSED WITH CHRONIC FINASTERIDE THERAPY. IN THE RANDOMIZED TRIAL, TISSUE DHT LEVELSWERE REDUCED BY 32% FROM 6.49 TO 4.40 NG/G IN THE SPHB GROUP (P<0.005), WITH NO SIGNIFICANT CHANGE IN THE PLACEBO GROUP. |
| Dose amount | 320.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | TYPE EXT NOT STATED |
| Gender | MALE |