| Disease | EVALUATION OF THE HYPOCHOLESTEROIEMIC EFFECT OF ANENTERIC-COATED GARLIC SUPPLEMENT STANDARDIZED FOR ALLICIN-RELEASING POTENTIAL IN MILD TO MODERATE HYPERCHOLESTEROLEMIC PATIENTS. A DOUBLE-BLIND RANDOMIZED, PLACEBO-CONTROLLED INTERVENNTION STUDY
WAS CONDUCTED IN 46 HYPER-CHOLESTEEROLEMIC SUBJECTS WHO HAD FAILED OR WERE NOT COMPLAINT WITH DRUG THERAPY. EACH SUBJECT WAS GIVEN DIETARY COUNSELING TO LOWER FAT INTAKE AND ENTERIC-COATED AUSTRALIAN GARLIC POWDER TABLETS WITH 9.6 MG ALLICIN-
RELEASING POTENTIAL OR MATCHING PLACEBO TABLETS. AFTER 12 WEEKS, THE GARLIC SUPPLEMENT GROUP (N=22) HAD A SIGNIFICANT REDUCTION IN TOTAL CHOLESTEROL (TC,-0.36 MMOL/L, -4.2%) AND LDL-CHOLESTEROL (LDL-C, -0.44 MMOL/L, -6.6%) WHILE THE PLACEBO
GROUP (N=24) HAD A NON-SIGNIFICANT INCREASE IN TC(0.13 MMOL/L, 2.0%) AND LDL-C (0.18 MMOL/L, 3.7%).HDL-CHOLESTROL WAS SIGNIFICANTLY INCREASED IN THE PLACEBO GROUP (0.09 MMOL/L, 9.1%), COMPARED TO THE GARLIC GROUP (-0.02 MMOL/L, -0.9%), AND NO
SIGNIFICANT DIFFERENCE IN TRIGLYCERIDES OR IN LDL/HDL, RATIO WAS OBSERVERED BETWEEN GROUPS. THE STUDY DEMONSTRATES THAT ENTERIC-COATED GARLIC POWDER SUPPLEMENTS WITH 9.6 MG ALLICIN-RELEASING POTENTIAL MAY HAVE VALUE IN MILD TO MODERATE
HYPERCHOLESTEROLEMIC PATIENTS WHEN COMBINED WITH A LOW FAT DIET. |