Experiment 67885
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | HUBNER,WD: KIRSTE,T:. (2001). EXPERIENCE WITH ST JOHN'S WORT (HYPERICUM PERFORATUM) IN CHILDREN UNDER 12 YEARS WITH SYMPTOMS OF DEPRESSION AND PSYCHOVEGETATIVE DISTURBANCES.. 15(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE VALUE OF AN EXTRACT OF HYPERICUM PERFORATUM (ST JOHN'S WORT) FOR CHILDREN WITH MILD TO MODERATE DEPRESSIVE SYMPTOMS WAS INVESTIGATED FOR THE FIRST TIME IN A MULTI-CENTRE POST-MARKETING SURVEILLANCE STUDY. ONE HUNDRED AND ONE CHILDREN UNDER 12 YEARS WERE TREATED FOR A MINIMUM OF 4 WEEKS WITH AN EXTENSION TO 6 WEEKS WITH PARENTAL CONSENT AND MEDICAL PRACTITIONER RECOMMENDATION, THE DOSAGE USED RANGED FROM 300 TO 1800 MG PER DAY. COMPLIANCE, TOLERABILITY AND EFFICACY WERE ASSESSED EVERY 2 WEEKS BY PHYSICIANS AND PARENTS. BASED ON THE DATA AVAILABLE FOR ANALYSIS, THE NUMBER OF PHYSICIANS RATING EFFECTIVENESS AS 'GOOD' OR 'EXCELLENT' WAS 72% AFTER 2 WEEKS, 97% AFTER 4 WEEKS AND 100% AFTER 6 WEEKS. THE RATINGS BY PARENTS WERE VERY SIMILAR. THERE WAS, HOWEVER, AN INCREASING AMOUNT OF MISSING DATA AT EACH ASSESSMENT POINT WITH THE FINAL EVALUATION INCLUDING ONLY 76% OF THE INITIAL SAMPLE. TOLERABILITY WAS GOOD AND NO ADVERSE EVENTS WERE REPORTED. THE RESULTS OF THIS STUDY SUGGEST THAT HYPERICUM IS A POTENTIALLY SAFE AND EFFECTIVE TREATMENT FOR CHILDREN WITH SYMPTOMS OF DEPRESSION. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN CHILD |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |