Experiment 67905
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Mentha piperita (LAMIACEAE) |
| Citation | PIMENTEL,M: BONORRIS,GG: CHOW,EJ: LIN,HC:. (2001). PEPPERMINT OIL IMPROVES THE MANOMETRIC FINDINGS IN DIFFUSE ESOPHAGEAL SPASM.. 33(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | EIGHT CONSECUTIVE PATIENTS WITH CHEST PAIN OR DYSPHAGIA AND WHO WERE FOUND TO HAVE DES WERE ENROLLED DURING THEIR DIAGNOSTIC ESOPHAGEAL MANOMETRY. AN EIGHT-CHANNEL PERFUSION MANOMETRY SYSTEM WAS USED. LOWER ESOPHAGEAL SPHINCTER PRESSURE AND CONTRACTIONS OF THE ESOPHAGEAL BODY AFTER 10 WET SWALLOWS WERE ASSESSED BEFORE AND 10 MINUTES AFTER THE INGESTION OF A SOLUTION CONTAINING FIVE DROPS OF PEPPERMINT OIL IN 10 ML OF WATER. EACH SWALLOW WAS ASSESSED FOR DURATION (SECONDS), AMPLITUDE (MM HG), AND PROPORTION OF SIMULTANEOUS AND MULTIPHASIC ESOPHAGEAL CONTRACTIONS. LOWER ESOPHAGEAL SPHINCTER PRESSURES AND CONTRACTILE PRESSURES AND DURATIONS IN BOTH THE UPPER AND LOWER ESOPHAGUS WERE NO DIFFERENT BEFORE AND AFTER THE PEPPERMINT OIL, PEPPERMINT OIL COMPLETELY ELIMINATED SIMULTANEOUS ESOPHAGEAL CONTRACTIOONS IN ALL PATIENTS (P<0.01). THE NUMBER OF MULTIPHASIC, SPONTANEOUS, AND MISSED CONTRACTIONS ALSO IMPROVED. BECAUSE NORMAL ESOPHAGEAL CONTRACTIONS ARE CHARACTERISTICALLY UNIFORM IN APPEARANCE, VARIABILITY OF ESOPHAGEAL CONTRACTIONS WAS COMPARED BEFORE AND AFTER TREATMENT. THE VARIABILITY OF AMPLITUDE IMPROVED FROM 33.4(DL)-11.0 MM HG (P<0.05) AFTER THE PEPPERMINT OIL. THE VARIABILITY FOR DURATION IMPROVED FROM 2.02(DL)-1.80 TO 1.36(DL0-0.72 SECONDS (P<0.01). TWO OF THE EIGHT PATIENTS HAD CHEST PAIN THAT RESOLVED AFTER THE PEPPERMINT OIL. THIS DATA DEMONSTRATES THAT PEPPERMINT OIL IMPROVES THE MANOMETRIC FEATURES. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | ESSENTIAL OIL |
| Gender | GIVEN TO BOTH SEXES |