Experiment 67914
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Vaccinium macrocarpon (ERICACEAE) |
| Citation | KONTIOKARI,T: SUNDQVIST,K: NUUTINEN,M: POKKA,T: KOSKELA,M: UHARI,M:. (2001). RANDOMISED TRIAL OF CRANBERRY-LINGONBERRY JUICE AND LACTOBACILLUS GG DRINK FOR THE PREVENTION OF URINARY TRACT INFECTIONS IN WOMEN.. 322(7302) |
| Amount utilized | |
| Compound isolated | |
| Disease | AN OPEN, RANDOMISED CONTROLLED 12 MONTH FOLLOW UP TRIAL. INVOLVING 150 WOMEN WITH URINARY TRACT INFECTION CAUSED BY ESCHERICHIA COLI RANDOMLY ALLOCATED INTO THREE GROUPS. SUBJECTS WERE GIVEN 50 ML OF CRANBERRY-LINGONBERY JUICE CONCENTRATE DAILY FOR SIX MONTHS OR 100 ML OF LACTOBACILLUS DRINK FIVE DAYS A WEEK FOR ONE YEAR, OR NO INTERVENTION. MAIN OUTCOME MEASURE WAS TEH FIRST RECURRENCE OF SYMPTOMATIC URINARY TRACT INFECTION, DEFINED AS BACTERIAL GROWTH>10-5 COLONY FORMING UNITS/ML IN A CLEAN VOIDED MIDSTREAM URINE SPECIMEN. THE CUMULATIVE RATE OF FIRST RECURRENCE OF URINARY TRACT INFECTION DURING THE 12 MONTH FOLLOW UP DIFFERED SIGNIFICANTLY BETWEEN THE GROUPS (P=0.048). AT SIX MONTHS, EIGHT (16%) WOMEN IN THE CRANBERRY GROUP, 19(39%) IN THE LACTOBACILLUS GROUP, AND 18 (36%) IN THE CONTROL GROUP HAD HAD AT LEAST ON RECURRENCE. THIS IS A 20% REDUCTION IN ABSOLUTE RISK IN THE CRANBERRY GROUP COMPARED WITH THE CONTROL GROUP (95% CONFIDENCE INTERVAL 3% TO 36%, P=0.023, NUMBER NEEDED TO TREAT=5.95% CONFIDENCE INTERVAL 3 TO 34). REGULAR DRINKING OF CRANBERRY JUICE BUT NOT LACTOBACILLUS SEEMS TO REDUCE THE RECURRENCE OF URINARY TRACT INFECTION. |
| Dose amount | 50.0 ML |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | JUICE |
| Gender | FEMALE |