Experiment 67926
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Camellia sinensis (THEACEAE) |
| Citation | DUFFY,SJ: KEANEY,JF: HOLBROOK,M: GOKCE,N: SWERDLOFF,PL: FREI,B: VITA,JA:. (2001). SHORT- AND LONG-TERM BLACK TEA CONSUMPTION REVERSES ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH CORONARY ARTERY DISEASE.. 104(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | TO TEST THE HYPOTHESIS THAT TEA CONSUMPTION WILL REVERSE ENDOTHELIAL DYSFUNCTION, 66 PATIENTS WITH PROVEN CORONARY ARTERY DISEASE WERE RANDOMIZED TO CONSUME BLACK TEA AND WATER IN A CROSSOVER DESIGN. SHORT-TERM EFFECTS WERE EXAMINED 2 HOURS AFTER CONSUMPTION OF 450 ML TEA OR WATER. LONG-TERM EFFECTS WERE EXAMINED AFTER CONSUMPTION OF 900 ML TEA OR WATER DAILY FOR 4 WEEKS. VASOMOTOR FUNCTION OF THE BRACHIAL ARTERY WAS EXAMINED AT BASELINE AND AFTER EACH INTERVENTION WITH VASCULAR ULTRASOUND. FIFTY PATIENTS COMPLETED THE PROTOCOL AND HAD TECHNICALLY SUITABLE ULTRASOUND MEASUREMENTS. BOTH SHORT-AND LONG-TERM TEA CONSUMPTION IMPROVED ENDOTHELIUM-DEPENDENT FLOW-MEDIATED DILATION OF THE BRACHIAL ARTERY, WHEREAS CONSUMPTION OF WATER HAD NO EFFECT (P<0.001). TEA CONSUMPTION HAD NO EFFECT ON ENDOTHELIUM-INDEPENDENT NITROGLYCERIN-INDUCED DILATION. AN EQUIVALENT ORAL DOSE OF CAFFEINE (200MG) HAD NO SHORT-TERM EFFECT ON FLOW-MEDIATED DILATION. PLASMA FLAVONOIDS INCREASED AFTER SHORT-AND LONG-TERM TEA CONSUMPTION. SHORT-AND LONG-TERM BLACK TEA CONSUMPTION REVERSES ENDOTHELIAL VASOMOTOR DYSFUNCTION IN PATIENTS WITH CORONARY ARTERY DISEASE. THIS FINDING MAY PARTLY EXPLAIN THE ASSOCIATION BETWEEN TEA INTAKE AND DECREASED CARDIOVASCULAR DISEASE EVENTS. |
| Dose amount | 900.0 ML |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | H2O EXT |
| Gender | GIVEN TO BOTH SEXES |