Experiment 67930
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Uncaria tomentosa (RUBIACEAE) |
| Citation | SHENG,Y: LI,L: HOLMGREN,K: PERO,RW:. (2001). DNA REPAIR ENHANCEMENT OF AQUEOUS EXTRACTS OF UNCARIA TOMENTOSA IN A HUMAN VOLUNTEER STUDY.. 8(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE UNCARIA TOMENTOSA WATER EXTRACTS (C-MED-100) HAVE BEEN SHOWN TO ENHANCE DNA REPAIR, MITOGENIC RESPONSE AND LEUKOCYTE RECOVERY AFTER CHEMOTHERAPY-INDUCED DNA DAMAGE IN VIVO. IN THIS STUDY, THE EFFECT OF C-MED-100 SUPPLEMENT WAS EVALUATED IN A HUMAN VOLUNTEER STUDY. TWELVE APPARENTLY HEALTHY ADULTS WORKING IN THE SAME ENVIRONMENT WERE RANDOMLY ASSIGNED INTO 3 GROUPS WITH AGE AND GENDER MATCHED. ONE GROUP WAS DAILY SUPPLEMENTED WITH A 250 MG TABLET CONTAINING AN AQUEOUS EXTRACT OF UNCARIA TOMENTOSA OF C-MED-100, AND ANOTHER GROUP WITH A 350 MG TABLET, FOR 8 CONSECUTIVE WEEKS. DNA REPAIR AFTER INDUCTION OF DNA DAMAGE BY A STANDARD DOSE OF HYDROGEN PEROXIDE WAS MEASURED 3 TIMES BEFORE SUPPLEMENT AND 3 TIMES AFTER THE SUPPLEMENT FOR THE LAST 3 WEEKS OF THE 8 WEEK-SUPPLEMENT PERIOD. THERE WERE NO DRUG-RELATED TOXIC RESPONSES TO C-MED-100 SUPPLEMENT WHEN JUDGED IN TERMS OF CLINICAL SYMPTOMS, SERUM CLINICAL CHEMISTRY, WHOLE BLOOD ANALYSIS AND LEUKOCYTE DIFFERENTIAL COUNTS. THERE WAS A STATISTICALLY SIGNIFICANT DECREASE OF DNA DAMAGE AND A CONCOMITANT INCREASE OF DNA REPAIR IN THE SUPPLEMENT GROUPS (250 AND 350MG/DAY) WHEN COMPARED WITH NON-SUPPLEMENTD CONTROLS(P<0.05). THERE WAS ALSO AN INCREASED TENDENCY OF PHA INDUCED LYMPHOCYTE PROLIFERATION IN THE TREATMENT GROUPS. A COMMERCIAL PRODUCT, C-MED-100, WAS USED. |
| Dose amount | 50.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | CD90 |
| Extract | H2O EXT |
| Gender | GIVEN TO BOTH SEXES |