Experiment 68030
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | RYU,S: CHOI,SK: JOUNG,SS: SUH,H: CHA,YS: LEE,S: LIM,K:. (2001). CAFFEINE AS A LIPOLYTIC FOOD COMPONENT INCREASES ENDURANCE PERFORMANCE IN RATS AND ATHLETES.. 47(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | HUMAN SUBJECTS INGESTED THE CAFFEINE (5 MG/KG) 1 HPRIOR TO THE EXERCISE ON A CYCLE ERGOMETER AT 60% OF THEIR VO2MAX FOR 45 MIN. AND THEN THE EXERCISE INTENSITY WAS INCREASED TO 80% OF THEIR VO2MAX UNTIL EXHAUSTION. BLOOD AND BREATHING GAS SAMPLES WERE COLLECTED AND CALCULATED EVERY 10 MINDURING EXERCISE. RESPIRATORY EXCHANGE RATIO OF THECAFFEINE TRIAL WAS SIGNIFICANTLY LOWER THAN THAT OF THE PLACEBO TRIAL IN THE ATHLETES' STUDY (P<0.05). BLOOD FREE FATTY ACID (FFA) LEVELS IN STUDIES OF BOTH RATS AND ATHLETES WERE INCREASED BY CAFFEINE INGESTION DURING EXERCISE (P<0.05). BLOOD LACTATE LEVELS WERE ALSO INCREASED DURING EXERCISE IN BOTH RATS AND ATHLETES (P<0.05). INCREASED FFA AND GLYCEROL CONCENTRATIONS REDUCED GLYCOGEN UTILIZATION DURING EXERCISE COMPARED WITH PLACEBO GROUP IN RATS. IN ADDITION, ENDURANCE TIMETO EXHAUSTION WAS SIGNIFICANTLY INCREASED BY THE CAFFEINE INGESTION IN BOTH RATS AND ATHLETES (P<0.05). THESE RESULTS SUGGEST THAT THE CAFFEINE INGESTION ENHANCED ENDURANCE PERFORMANCE RESULTING FROM SPARE STORED GLYCOGEN WITH INCREASING LIPOLYSIS FROM ADIPOSE TISSUES AND FAT OXIDATION DURING EXERCISE IN ATHLETES. |
| Dose amount | 5.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |