| Disease | A NOVEL RED CLOVER ISOFLAVONE PREPARATION (RIMOSTIL) CONTAINING GENISTEIN, DAIDZEIN, FORMONONETIN, AND BIOCHANIN WAS ADMINISTERED TO 46 POSTMENOPAUSAL WOMEN IN A DOUBLE-BLIND PROTOCOL AFTER A SINGLE-BLIND PLACEBO PHASE AND FOLLOWED BY A SINGLE-
BLIND WASHOUT PHASE. PATIENTS WERE RANDOMIZED TO RECEIVE EITHER 28.5 MG, 57 MG, OR 85.5 MG OF PHYTOESTROGENS DAILY FOR A 6-MONTH PERIOD. AT 6 MONTHS, THE SERUM HIGH-DENSITY LIPOPROTEIN CHOLESTEROL HADRISEN SIGNIFICANTLY BY 15.7-28.6% WITH
DIFFERENT DOSES (P=0.007, P=0.002, P=0.027), ALTHOUGH THE MAGNITUDE OF THE RESPONSE WAS INDEPENDENT OF THE DOSE USED. THE SERUM APOLIPOPROTEIN B FELL SIGNIFICANTLY BY 11.5-17.0% WITH DIFFERENT DOSES (P=0.005, P=0.043, P=0.007) AND THE MAGNITUDE
OF THE RESPONSE WAS INDEPENDENT OF THE DOSE USED. THE BONE MINERAL DENSITY OF THE PROXIMAL RADIUS AND ULNA ROSE SIGNIFICANTLY BY 4.1% OVER 6 MONTHS WITH 57 MG/DAY (P=0.002) AND BY 3.0% WITH 85.5 MG/DAY (P=0.023) OF ISOFLAVONES. THE RESPONSE WITH
28.5 MG/DAY OF ISOFLAVONES WAS NOT SIGNIFICANT. THERE WAS NO SIGNIFICANT INCREASE IN ENDOMETRIAL THICKNESS WITH ANY OF THE DOSES OF ISOFLAVONE USED. THESE RESULTS SHOW THAT THE ADMINISTRATION OF AN ISOFLAVONE COMBINATION EXTRACTED FROM RED
CLOVER WAS ASSOCIATED WITH A SIGNIFICANT INCREASE IN HIGH-DENSITY LIPOPROTEIN CHOLESTEROL, A SIGNIFICANT FALL IN APOLIPOPROTEIN B, AND A SIGNIFICANT INCREASE IN THE PREDOMINANTLY CORTICAL BONE OF THE PROXIMAL RADIUS AND ULNA AFTER 6 MONTHS OF
TREATMENT. INTERPRETATION OF THE RESULTS IS UNDER-TAKEN CAUTIOUSLY BECAUSE OF THE ABSENCE OF A SIMULTANEOUSLY STUDIED CONTROL GROUP. |