Experiment 68065
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Glycyrrhiza glabra (FABACEAE) |
| Citation | SIGURJONSDOTTIR,HA: FRANZSON,L: MANHEM,K: RAGNARSSON,J: SIGURDSSON,G: WALLERSTEDT,S:. (2001). LIQUORICE-INDUCED RISE IN BLOOD PRESSURE: A LINEAR DOSE-RESPONSE RELATIONSHIP.. 15(8) |
| Amount utilized | |
| Compound isolated | |
| Disease | TO CLARIFY THE DOSE-RESPONSE AND THE TIME-RESPONSE RELATIONSHIP BETWEEN LIQUORICE CONSUMPTION AND RISE IN BLOOD PRESSURE AND EXPLORE THE INTER-INDIVIDUAL VARIANCE. THIS INTERVENTION STUDY WAS DESIGNED AND EXECUTED IN RESEARCH LABORATORIES AT UNIVERSITY HOSPITALS IN ICELAND AND SWEDEN. HEALTHY, CAUCASIAN VOLUNTEERS WHO ALSO SERVED AS A CONTROL FOR HIMSELF/HERSELF CONSUMED LIQUORICE IN VARIOUS DOSES, 50-200 G/DAY, FOR 2-4 WEEKS, CORRESPONDING TO A DAILY INTAKE OF 75-540 MG GLYCYRRHETINIC ACID, THE ACTIVE SUBSTANCE IN LIQUORICE. BLOOD PRESSURE WAS MEASURED BEFORE, DURING AND AFTER LIQUORICE CONSUMPTION. SYSTOLIC BLOOD PRESSURE INCREASED BY 3.1-14.4 MM HG (P<0.05 FOR ALL), DEMONSTRATING A DOSE-RESPONSE BUT NOT A TIME-RESPONSE RELATIONSHIP. THE INDIVIDUAL RESPONSE TO LIQUORICE FOLLOWED THE NORMAL DISTRIBUTION. SINCE LIQUORICE RAISED THE BLOOD PRESSURE WITH A LINEAR DOSE-RESPONSE RELATIONSHIP, EVEN DOSES AS LOW AS 50 G OF LIQUORICE (75 MG GLYCYRRHETINIC ACID) CONSUMED DAILY FOR 2 WEEKS CAN CAUSE A SIGNIFICANT RISE IN BLOOD PRESSURE. |
| Dose amount | 100.0 GM |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | ROOT |
| Gender | GIVEN TO BOTH SEXES |