Experiment 68072
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Valeriana officinalis (VALERIANACEAE) |
| Citation | DOMINGUEZ,RA: BRAVO VALVERDE,RL: KAPLOWITZ,BR: COTT,JM:. (2000). VALERIAN AS A HYPNOTIC FOR HISPANIC PATIENTS.. 6(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | TWENTY-THREE ESTABLISHED OUTPATIENT SYMPTOMATIC HISPANIC VOLUNTEERS RECEIVING MENTAL HEALTH SERVICESAT A LARGE URBAN HOSPITAL PARTICIPATED IN THIS CASE STUDY. ALL COMPLAINED OF INSUFFICIENT SLEEP. THEY WERE ASKED TO TRY A POPULAR NATIONAL BRAND OF VALERIAN ("NATURE'S WAY", 470 MG VALERIANROOT) AND COMPLETED SLEEP QUESTIONNAIRES AT BASELINE AND AT THE END OF WEEKS 1 AND 2. THEY WERE INSTRUCTED TO TAKE 1 CAPSULE EACH NIGHT BEFORE RETIRING AND WERE ALLOWED TO INCREASE THEIR DOSE TO A MAXIMUM OF 3 CAPSULES AFTER WEEK 1. TWENTY PATIENTS COMPLETED THE TRIAL. ON AN ORDINAL SCALE OF 1 (NO EFFECT) (MODERATELY HELPFUL), AND 5 (EXTREMELYHELPFUL), 16 PATIENTS RATED THEIR INSOMNIA AS AT LEAST "MODERATELY IMPROVED" AT THE END OF WEEK 1. BY WEEK 2, 16 STILL RATED THEMSELVES AT LEAST "MODERATELY IMPROVED," BUT 15 OF THEM NOW DESCRIBEDTHEIR RESPONSE AS EITHER A 4 OR A 5. GLOBAL IMPROVEMENT AT WEEK 2 WAS SIGNIFICANTLY BETTER THAN AT WEEK 1 (WILCOXON RANKS TEST P=.005), PERHAPS REFLECTING A TIME-DEPENDENT OR DOSE-RESPONSE RELATIONSHIP. THIS CASE STUDY SUGGESTS THAT VALERIAN CAN BE A SUPPLEMENT FOR IMPROVING INSOMNIA IN A SYMPTOMATIC POPULATION . |
| Dose amount | 470.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | ROOT |
| Gender | GIVEN TO BOTH SEXES |