Experiment 68078
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | SHELTON,RC: KELLER,MB: GELENBERG,A: DUNNER,DL: HIRSCHFELD,R: THASE,ME: RUSSELL,J: LYDIARD,RB: CRITS-CRISTOPH,P: GALLOP,R: TODD,L: HELLERSTEIN,D: GOODNICK,P: KEITNER,G: STAHL,SM: HALBREICH,U:. (2001). EFFECTIVENESS OF ST JOHN'S WORT IN MAJOR DEPRESSION. A RANDOMIZED CONTROLLED TRIAL.. 285(15) |
| Amount utilized | |
| Compound isolated | |
| Disease | TO COMPARED THE EFFICACY AND SAFETY OF A STANDARDIZED EXTRACT OF ST JOHN'S WORT WITH PLACEBO IN OUTPATIENTS WITH MAJOR DEPRESSION. RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL CONDUCTED BETWEEN NOVEMBER 1998 AND JANUARY 2000. TWO HUNDRED ADULT OUTPATIENTS DIAGNOSED AS HAVING MAJOR DEPRESSION AND HAVING A BASELINE HAMILTON RATING SCALE FOR DEPRESSION (HAM-D) SCORE OF AT LEAST 20 COMPLETED A 1-WEEK, SINGLE-BLIND RUN-IN OF PLACEBO, THEN WERE RANDOMLY ASSIGNED TO RECEIVE EITHER ST JOHN'S WORT EXTRACT (N-98; 900 MG/D FOR 4 WEEKS, INCREASED TO 1200 MG/D IN THE ABSENCE OF AN ADEQUATE RESPONSE THEREAFTER) OR PLACEBO (N-102) FOR 8 WEEKS. THE PRIMARY OUTCOME MEASURE WAS RATE OF CHANGE ON THE HAM-D OVER THE TREATMENT PERIOD. THE RANDOM COEFFICIENT ANALYSES FOR THE HAM-D, HAM-A, CGI-S, AND CGI-I ALL SHOWED SIGNIFICANT EFFECTS FOR TIME BUT NOT FOR TREATMENT OR TIME-BY-TREATMENT INTERACTION. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |