Experiment 68086
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Zingiber officinale (ZINGIBERACEAE) |
| Citation | VUTYAVANICH,T: KRAISARIN,T: RUANGSRI,RA:. (2001). GINGER FOR NAUSEA AND VOMITING IN PREGNANCY: RANDOMIZED, DOUBLE-MASKED, PLACEBO-CONTROLLED TRIAL.. 97(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | WOMEN WITH NAUSEA AND VOMITING OF PREGNANCY, WHO FIRST ATTENDED AN ANTENATAL CLINIC AT OR BEFORE 17 WEEKS' GESTATION, WERE INVITED TO PARTICIPATE IN THE STUDY. DURING A 5-MONTH PERIOD, 70 ELIGIBLE WOMEN GAVE CONSENT AND WERE RANDOMIZED IN A DOUBLE-MASKED DESIGN TO RECEIVE EITHER ORAL GINGER 1 G PER DAY OR AN IDENTICAL PLACEBO FOR 4 DAYS. SUBJECTS GRADED THE SEVERITY OF THEIR NAUSEA USING VISUAL ANALGO SCALES AND RECORDED THE NUMBER OF VOMITING EPISODES IN THE PREVIOUS 24 HOURS BEFORE TREATMENT, AND AGAIN DURING 4 CONSECUTIVE DAYS WHILE TAKING TREATMENT. AT A FOLLOW-UP VISIT 7 DAYS LATER, FIVE-ITEM LIKERT SCALES WERE USED TO ASSESS THE SEVERITY OF THEIR SYMPTOMS. THE VISUAL ANALOG SCORES OF POST-THERAPY MINUS BASELINE NAUSEA DECREASED SIGNIFICANTLY IN THE GINGER GROUP COMPARED WITH THE PLACEBO GROUP. THE NUMBER OF VOMITING EPISODES ALSO DECREASED SIGNIFICANTLY IN THE GINGER GROUP. LIKERT SCALES SHOWED THAT THE GINGER GROUP HAD IMPROVEMENT IN NAUSES SYMPTOMS COMPARED WITH THE PLACEBO GROUP. NO ADVERSE EFFECT OF GINGER ON PREGNANCY OUTCOME WAS DETECTED. |
| Dose amount | 1.0 GM |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN(PREGNANT) |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | ROOT |