Experiment 68113
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | GOHO,C:. (2001). ORAL MIDAZOLAM - GRAPEFRUIT JUICE DRUG INTERACTION.. 23(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | WHEN ORAL MIDAZOLAM IS GIVEN WITH GRAPEFRUIT JUICE, THE CLINICAL EFFECT OF INHIBITED CYP3A4 IS A 56% INCREASE IN PEAK PLASM CONCENTRATION (MAX) OF MIDAZOLAM AND A 79% INCREASE IN THE TIME REQUIRED TO REACH THE PEAK PLASMA CONCENTRATION (TMAX) (FROM 0.62 HOURS TO 1.11 HOURS). CLEARNACE AND ELIMINATION OF MIDAZOLAM ARE NOT AFFECTED. THE END RESULT OF THE VARIOUS INHIBITIONS OF CYP3A4 IS AN INCREASE IN THE BIAVAILABILITHY OF MIDAZOLAM BY 35%, LEADING TO THE POSSIBILITY OF EXCESSIVE SEDATION. |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN CHILD |
| Dose expression | DOSE |
| Extract | JUICE |
| Gender | GIVEN TO BOTH SEXES |