Experiment 68130
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | LOIZOU,GD: COCKER,J:. (2001). THE EFFECTS OF ALCOHOL AND DIALLY SULPHIDE ON CYP2E1 ACTIVITY IN HUMANS: A PHENOTYPING STUDY USING CHLORZOXAZONE.. 20(7) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE EFFECTS OF ACUTE ADMINISTRATIONOF DIETARY LEVELS OF ETHANOL AND THE GARLIC OIL EXTRACT, DIALLYL SULPHIDE (DAS), ON CYTOCHROME P450 2E1 (CYP3E1) ACTIVITY INVOLUNTEERS WERE STUDIED USING THE SELECTIVE PROBE SUBSTRATE, CHLORZOXANE (CZX). THE RATIO OF THE CZX METABOLITE 6-HYDROXYCHLORZOXAZONE (6-OHCZX) TO CZX WAS TAKEN TO INDICATE CYP2E1 ACTIVITY. THE MEAN DIFFERENCES BETWEEN THE BASELINE AND DAS-TREATED (0.2 MG/KG) CYP2E1 ACTIVITIES WERE SIGNIFICANTLY DIFFERENT (TWO-TAILED P VALUE= 0.0242, N=8). LIKE-WISE, THE MEAN DIFFERENCES BETWEEN THE BASELINE AND EGTHANOL-TREATED (0.8 G/KG) CYP2E1 ACTIVITIES WERE ALSO SIGNIFICANTLY DIFFERENT (TWO-TAILED P VALUE = 0.0005,N=7). |
| Dose amount | 0.2 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |