Experiment 68189
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | PETRIE,EC: PESKIND,ER: DOBIE,DJ: VEITH,RC: RASKIND,MA:. (2000). INCREASED PLASMA NOREPINEPHRINE RESPONSE TO YOHIMBINE IN ELDERLY MEN.. 55A(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | YOHIMBINE (0.65 MG/KG), CLONIDINE (5 UG/KG), AND PLACEBO WERE ADMINISTERED ON SEPARATE DAYS IN RANDOM ORDER TO 5 HEALTHY OLDER MEN (AGE 74+1 YEARS) AND 18 HEALTHY YOUNG MEN (AGE 26+1 YEARS). NE AND EPI WERE MEASURED BY RADIOENZYMATIC ASSAY IN PLASMA SAMPLES OBTAINED BEFORE AND 30,60 AND 90 MINUTES AFTER DRUG ADMINSTRATION. PLASMA NE INCREASES AFTER YOHIMBINE WERE GREATER IN OLDER MEN THAN IN YOUNG MEN, BUT PLASMA NE DECREASES FOLLOWING CLONIDINE DID NOT DIFFER BETWEEN GROUPS. PLASMA NE AND SYSTOLIC BLOOD PRESSURE WERE HIGHER IN OLDER MEN THAN IN YOUNGER MEN AT BASELINE BUT NO LONGER DIFFERED 90 MINUTES AFTER CLONIDINE, PLASMA EPI INCREASES AFTER YOHIMBINE AND DECREASES AFTER CLONIDINE DID NOT DIFFER BETWEEN GROUPS. |
| Dose amount | 0.65 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |