Experiment 68196
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Glycine max (FABACEAE) |
| Citation | MITCHELL,JH: CAWOOD,E: KINNIBURGH,D: PROVAN,A: COLLINS,AR: IRVINE,DS:. (2001). EFFECT OF PHYTOESTROGEN FOOD SUPPLEMENT ON REPRODUCTIVE HEALTH IN NORMAL MALES.. 100(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE STUDY DETERMINES THE EFFECTS OF A SHORT-TERM PHYTOESTROGEN SUPPLEMENT ON SEMEN QUALITY AND SERUM SEX STEROID AND GONADOTROPHIN LEVELS IN HUMAN MALES. HEALTHY VOLUNTEERS TOOK A SUPPLEMENT CONTAINING 40 MG OF ISOFLAVONES DAILY FOR 2 MONTH AND DONATED BLOOD AND SEMEN SAMPLES MONTHLY FOR 2 MONTHS BEFORE AND 4 MONTHS AFTER SUPPLEMENTATION. SEMEN SAMPLES WERE ANALYSED FOR EJACULATE VOLUME, SPERM CONCENTRATION, TOTAL SPERM COUNT, MOTILITY AND MORPHOLOGY. BLOOD SAMPLES WERE ANALYSED FOR SEX HORMONE AND GONADOTROPHIN LEVELS AND PHYTOESTROGEN CONCENTRATIONS, AND TESTICULAR VOLUME WAS MEASURED USING AN ORCHIDOMETER. THE PHYTOESTROGEN SUPPLEMENT INCREASED PLASMA GENISTEIN AND DAIDZEIN CONCENTRATIONS TO APPROX. 1 MICROMOL AND 0.5 MICROGM RESPECTIVELY; YET, THERE WAS NO OBSERVABLE EFFECT ON ENDOCRINE MEASUREMENTS, TESTICULAR VOLUME OR SEMEN PARAMETERS OVER THE STUDY PERIOD. THIS IS THE FIRST STUDY TO EXAMINE THE EFFECTS OF A PHYTOESTROGEN SUPPLEMENT ON REPRODUCTIVE HEALTH IN MALES, WE CONCLUDE THAT THE PHYTOESTROGEN DOSE CONSUMED HAD NO EFFECT ON SEMEN QUALITY. |
| Dose amount | 500.0 MG |
| Number | 2 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | TYPE EXT NOT STATED |
| Gender | MALE |