Experiment 68200
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | UNO,T: OHKUBO,T: SUGAWARA,K: HIGASHIYAMA,A: MOTOMURA,S: ISHIZAKI,T:. (2000). EFFECTS OF GRAPEFRUIT JUICE ON THE STEREOSELECTIVE DISPOSITION OF NICARDIPINE IN HUMANS: EVIDENCE OF DOMINANT PRESYSTEMIC ELEMINATION AT THE GUT SITE.. 56(9/10) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE KINETIC PROFILES OF (+)- AND (-)-NICARDIPINE WERE STUDIED IN THE SIX NORMAL HEALTHY MALE VOUNTEERS WHO RECEIVED ORAL (40 MG) AND INTRAVENOUS (2 MG) RACEMIC NICARDIPINE, FIRST WITH WATER AND SECOND WITH GRAPEFRUIT JUICE. BOTH THE ENANTIOMERS WERE DETERMINED BY THE STEREOSELECTIVE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD, AND HEMODYNAMIC PARAMETES (ARTERIAL BLOOD PRESSURE, HEART RAT, AND ELECTROCARDIOGRAM) WERE ASSESSED WHEN EACH BLOOD SAMPLE WAS TAKEN. GRAPEFRUIT JUICE COMPARED WITH WATER INTAKE CAUSED A SIGNIFICANT (P<0.05) INCREASE IN MEAN ORAL (+)- AND (-)-NICARDIPINE BIOAVAILABILITY(FOBS) (48.6+5.0% AND 105.6+7.8%) AND DOSE-ABSORBED (FABS) 5.6% AND 110.9+8.8%, RESPECTIVELY) WITH NO SIGNIFICANT CHANGE IN THE HEPATIC FIRST-PASS EFFECT. |
| Dose amount | 300.0 ML |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | JUICE |