Experiment 68225

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismLinum usitatissimum (LINACEAE)
CitationHUTCHINS,AM: MARTINI,MC: OLSON,BA: THOMAS,W: SLAVIN,JL:. (2001). FLAXSEED CONSUMPTION INFLUENCES ENDOGENOUS HORMONE CONCENTRATIONS IN POSTMENOPAUSAL WOMEN.. 39(1)
Amount utilized
Compound isolated
DiseaseTHIS RANDOMIZED CROSSOVER TRIAL CONSISTED OF THREE SEVEN-WEEK FEEDING PERIODS, DURING WHICH 28 POSTMENOPAUSAL WOMEN, AGED 52-82 YR, CONSUMED THEIR HABITUAL DIETS PLUS 0,5, OR 10 G OF GROUND FLAXSEED. SERUM SAMPLES COLLECTED DURING THE LAST WEEK OF EACH FEEDING PERIOD WERE ANALYZED FOR SERUM HORMONES USING STANDARD DIAGNOSTIC KITS. THE FLAXSEED DIETS SIGNIFICANTLY REDUCED SERUM CONCENTRATIONS OF 17BETA-ESTRADIOL BY 3.26 PG/ML (12.06 PMOL/L) AND ESTRONE SULFATE BY 0.09 NG/ML (0.42 NMOL/L) AND INCREASED PROLACTIN BY 1.92 UG/L (0.05 IU/ML). SERUM CONCENTRATIONS OF ANDROSTENEDIONE, ESTRONE, SEX HORMONE-BINDING GLOBULIN, PROGESTERONE, TESTOSTERONE, FREE TESTOSTERONE, DEHYDROEPIANDROSTERONE, AND DEHYDROEPIANDROSTERONE SULFATE WERE NOT ALTERED WITH FLAXSEED FEEDING. IN THIS GROUP OF POSTMENOPAUSAL WOMEN, CONSUMING FLAXSEED IN ADDITION TO THEIR HABITUAL DIETS INFLUENCED THEIR ENDOGENOUS HORMONE METABOLISM BY DECREASING SERUM 17BETA-ESTRADIOL AND ESTRONE SULFATE AND INCREASING SERUM PROLACTIN CONCENTRATIONS.
Dose amount10.0 GM
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitDAY
Dose expressionDOSE
ExtractSEEDS
GenderFEMALE