Experiment 68233
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Allium sativum (LILIACEAE) |
| Citation | ACKERMANN,RT: MULROW,CD: RAMIREZ,G: GARDNER,CD: MORBIDONI,L: LAWRENCE,VA:. (2001). GARLIC SHOWS PROMISE FOR IMPROVING SOME CARDIOVASCULAR RISK FACTORS.. 161(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | FROM 1798 PERTINENT RECORDS, 45 RANDOMIZED TRIALS AND 73 ADDITIONAL STUDIES REPORTING ADVERSE EVENTS WERE IDENTIFIED. TWO PHYSICIANS ABSTRACTED OUTCOMES AND ASSESSED ADEQUACY OF RANDOMIZATION, BLINDING, AND HANDLING OF DROPOUTS. STANDARDIZED MEAN DIFFERENCES OF LIPID OUTCOMES FROM PLACEBO-CONTROLLED TRIALS WERE ADJUSTED FOR BASELINE DIFFERENCES AND POOLED USING RANDOM EFFECTS METHODS. COMPARED WITH PLACEBO, GARLIC PREPARATIONS MAY LEAD TO SMALL REDUCTIONS IN THE TOTAL CHOLESTEROL LEVEL AT 1 MONTH (RANGE OF AVERAGE POOLED REDUCTIONS, 0.03-0.45 MMOL/L[1.2-17.3 MG/DL]) AND AT 3 MONTHS (RANGE OF AVERAGE POOLED REDUCTIONS 0.32-0.66 MMOL/L [12.4-25.4 MG/DL]), BUT NOT AT 6 MONTHS. CHANGES IN LOW-DENSITY LIPOPROTEIN LEVELS AND TRIGLYCERIDE LEVELS PARALLELED TOTAL CHOLESTEROL LEVEL RESULTS; NO STATISTICALLY SIGNIFICANT CHANGES IN HIGH-DENSITY LIPROPROTEIN LEVELS WERE OBSERVED. TRIALS ALSO REPORTED SIGNIFICANT REDUCTIONS IN PLATELET AGGREGATION AND MIXED EFFECTS ON BLOOD PRESSURE OUTCOMES. NO EFFECTS ON GLYCEMIC-RELATED OUTCOMES WERE FOUND. PROVEN ADVERSE EFFECTS INCLUDED MALODOROUS BREATH AND BODY ODOR. OTHER UNPROVEN EFFECTS INCLUDED FLATULENCE, ESOPHAGEAL AND ABDOMINAL PAIN, ALLERGIC REACTIONS, AND BLEEDING. |
| Dose amount | VAR |
| Number | 3 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | NH4OH EXT |
| Gender | GIVEN TO BOTH SEXES |