Experiment 68235
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Allium sativum (LILIACEAE) |
| Citation | ROSEN,RT: HISERODT,RD: FUKUDA,EK: RUIZ,RJ: ZHOU,Z: LECH,J: ROSEN,SL: HARTMAN,TG:. (2000). THE DETERMINATION OF METABOLITES OF GARLIC PREPARATIONS IN BREATH AND HUMAN PLASMA.. 13(1/4) |
| Amount utilized | |
| Compound isolated | |
| Disease | THESE GARLIC PREPNS. RELEASE ALLICIN, WHICH DECOMPS IN STOMACH ACID OR WITH TIME IN THE INTESTINE TO RELEASE ALLYL SULFIDES, DISULFIDES, AND OTHER VOLATILES, SOME OF WHICH ARE POSTULATED TO BE METABOLIZED BY GLUTATHIONE AND/OR S- ADENOSYLMETHIONINE TO FORM ALLYL ME SULFIDE, THE MAIN SULFUR CONTG. VOLATILE METABOLITE. S-ALLYCYSTEINE, A NON-VOLATILE BIOACTIVE COMPONENT OF AGED GARLIC PREPNS., WAS DETD. IN HUMAN PLASMA AND URINE BY HPLC-MS USING THE NEG. ION ATM. PRESSURE CHEM. IONIZATION MOD (APCL)-MS. THE TECHNIQUE OF SELECTED ION MONITORING WAS USED FOR QUANTITATION. A SYNTHETIC INTERNAL STD. OF DEUTERATED S-ALLCYSTEINE WAS ADDED TO THE PLASMA OR URINE TO ENSURE RECOVERY AND TO OBTAIN RELIABLE QUANT. DATA. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | CONC USED |
| Extract | BULB |