Experiment 68248
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Plantago ovata (PLANTAGINACEAE) |
| Citation | ANDERSON,JW: ALLGOOD,LD: LAWRENCE,A: ALTRINGER,LA: JERDACK,GR: HENGEHOLD,A: MOREL,JG:. (2000). CHOLESTEROL-LOWERING EFFECTS OF PSYLLIUM INTAKE ADJUNCTIVE TO DIET THERAPY IN MEN AND WOMEN WITH HYPERCHOLESTEROLEMIA: META-ANALYSIS OF 8 CONTROLLED TRIALS.. 71(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | META-ANALYSIS WAS CONDUCTED TO MORE PRECISELY DEFINE THE HYPOLIPIDEMIC EFFECTS AND SAFETY OF PSYLLIUM WHEN USED ADJUNCTIVE TO A LOW-FAT DIET IN MEN AND WOMEN WITH HYPERCHOLESTEROLEMIA. THE 8 STUDIES IN THE META-ANALYSIS INCLUDED A TOTAL OF 384 AND 272 SUBJECTS RECEIVING PSYLLIUM OR CELLULOSE PLACEBO, RESPECTIVELY. ALL STUDIES EVALUATED THE HYPOCHOLESTEROLEMIC EFFECTS OF 10.2 G PSYLLIUM/D ADJUNCTIVE TO A LOW-FAT DIET FOR >8 WK IN INDIVIDUALS WITH MILD-TO-MODERATE HYPERCHOLESTEROLEMIA AFTER A LOW-FAT DIET LEAD-IN PHASE LASTING >8 WK. THE SAFETY AND ADVERSE EVENTS ASSOCIATED WITH PSYLLIUM CONSUMPTION WERE SUMMARIZED FROM POOLED DATA OF 19 CLINICAL STUDIES RANGING FROM 6 WK TO 6 MO IN DURATION. CONSUMPTION OF 10.2 G PSYLLIUM/D LOWERED SERUM TOTAL CHOLESTEROL BY 4% (P<0.0001), LDL CHOLESTEROL BY 7% (P<0.0001), AND THE RATIO OF APOLIPOPROTEIN (APO) B TO APO 1-I BY 6% (P<0.05) RELATIVE TO PLACEBO IN SUBJECTS ALREADY CONSUMING A LOW-FAT DIET, WITH NO EFFECT ON SERUM HDL OR TRIACYLGLYCEROL CONCENTRATION. PSYLLIUM SUPPLEMENTATION SIGNIFICANTLY LOWERED SERUM TOTAL AND LDL-CHOLESTEROL CONCENTRATIONS IN SUBJECTS CONSUMING A LOW-FAT DIET. PSYLLIUM IS WELL TOLERATED AND SAFE WHEN USED ADJUNCTIVE TO A LOW-FAT DIET IN INDIVIDUALS WITH MILD-TO-MODERATE HYPERCHOLESTEROLEMIA. |
| Dose amount | 10.2 |
| Number | 2 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | SEED HUSKS |
| Gender | GIVEN TO BOTH SEXES |