Experiment 68253
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Piper methysticum (PIPERACEAE) |
| Citation | WARNECKE,G: PFAENDER,H: GERSTER,G: GRACZA,E:. (1990). WIRKSAMKIET VON KAWA-KAWA-EXTRAKT BEIM KLIMAKTERISCHEN SYNDROM.. 11() |
| Amount utilized | |
| Compound isolated | |
| Disease | IN A RANDOMIZED DOUBLE BLIND CLINICAL TRIAL THE EFFICACY OF A MONOPREPARATION CONTAINING AN EXTRACT OUT OF THE KOAVAROOT WAS TESTED AT 2 X 20 FEMALE PATIENTS WITH CLIMACTERIC SYNDROME OVER A RANGE OF 12 WEEKS. TO JUDGE EFFICACY KUPPERMANN-INDEX, ASI-SCALE AND A SPECIAL DIARY FOR THE PATIENTS WERE USED. FURTHER PARAMETERS WERE THE NUMBER OF PATIENTS BREAKING OFF THE THERAPY AND THE POSSIBILITY OF REDUCING THE DAILY DOSES. IN THE VERUM-GROUP THE DIFFERENCES IN COMPARISON WITH O WERE ALREADY 4 WEEKS AFTER BEGINNING HIGHLY SIGNIFICANT (P=0,001). 12 WEEKS AFTER BEGINNING NO STATISTICAL TESTING WAS ABLE BECAUSE IN THE PLACEBO-GROUP ONLY 6 PATIENTS REMAINED. 14 PATIENTS HAD BROKEN OFF THE THERAPY WITHIN WEEK 6 UNTIL 10 IN CONSEQUENCE OF ABSENT EFFECT. THE VERUM GROUP SHOWED ONLY 2 BREAKING OFFS. IN THE PLACEBEO-GROUP ALL PATIENTS TOOK 2 CAPSULES DAILY UNTIL THE INDIVIDUAL END OF THERAPY, WHEREAS 11 PATIENTS OF THE VERUM-GROUP REDUCED THE DAILY DOSE DOWN TO 1 CAPSULE DAILY WITHIN WEEK 6 UNTIL 11. THIS IS CORRESPONDING TO AN AVERAGE OF THE DAILY DOSE OF 43.5 MG KAVALACTONES IN THE WHOLE VERUM-GROUP AT THE END OF THE TRIAL. A SMALL LOWERING OF THE VIGILANCE, FOR EXAMPLE IN THE MORNING WERE INITIAL TOLD BY VERUM-PATIENTS. SMALL SIDE EFFECTS IN THE GASTROINTESTINAL REGION WERE TOLD BY 15% OF THE PLACEBO-PATIENTS BUT ONLY BY 10% OF THE VERUM-PATIENTS. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | TYPE EXT NOT STATED |
| Gender | FEMALE |