Experiment 68256
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Passiflora incarnata (PASSIFLORACEAE) |
| Citation | AKHONDZADEH,S: KASHANI,L: MOBASERI,M: HOSSEINI,SH: NIKZAD,S: KHANI,M:. (2001). PASSIONFLOWER IN THE TREATMENT OF OPIATES WITHDRAWAL: A DOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL.. 26(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE RESULTS OF A DOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL OF CLONIDINE PLUS PASSIFLORA EXTRACT VS. CLONIDINE PLUS PLACEBO IN THE OUTPATIENT DETOXIFICATION OF 65 OPIATES ADDICTS. A TOTAL OF 65 OPIATES ADDICTS WERE ASSIGNED RANDOMLY TO TREATMENT WITH PASSIFLORA EXTRACT PLUS CLONIDINE TABLE OR CLONIDINE TABLE PLUS PLACEBO DROP DURING A 14-DAY DOUBLE-BLIND CLINICAL TRIAL. ALL PATIENTS MET THE DSM IV CRITERIA FOR OPIOID DEPENDENCE. THE FIXED DAILY DOSE WAS 60 DROPS OF PASSIFLORA EXTRACT AND A MAXIMUM DAILY DOSE OF 0.8 MG OF CLONIDINE ADMINISTERED IN THREE DIVIDED DOSES. THE SEVERITY OF THE OPIATE WITHDRAWAL SYNDROME WAS MEASURED ON DAYS 0, 1, 2, 3, 4, 7 AND 14 USING THE SHORT OPIATE WITHDRAWL SCALE(SOWS). BOTH PROTOCOLS WERE EQUALLY EFFECTIVE IN TREATING THE PHYSICAL SYMPTOMS OF WITHDRAWAL SYNDROMES. HOWEVER, THE PASSIFLORA PLUS CLONIDINE GROUP SHOWED A SIGNIFICANT SUPERIORITY OVER CLONIDINE ALONE IN THE MANAGEMENT OF MENTAL SYMPTOMS. |
| Dose amount | 2.0 OUNCES |
| Number | 2 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | TYPE EXT NOT STATED |
| Gender | GIVEN TO BOTH SEXES |