Experiment 68257
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Centella asiatica (APIACEAE) |
| Citation | ICANDELA,L: BELCARO,G: CESARONE,MR: DE SANCTIS,MT: NARGI,E: PATRICELLI,P: BUCCI,M:. (2001). TREATMENT OF DIABETIC MICROANGIOPATHY AND EDEMA WITH TOTAL TRITERPENIC FRACTION OF CENTELLA ASIATICA: A PROSPECTIVE, PLACEBO-CONTROLLED RANDOMIZED STUDY.. 52(S2) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE AIM OF THIS STUDY WAS TO DEMONSTRATE IN A PROSPECTIVE, PLACEBO-CONTROLLED, RANDOMIZED STUDY, WHETHER TOTAL TRITERPENIC FRACTION OF CENTELLA ASIATICA (TTFCA) IS EFFECTIVE IN IMPROVING THE MICROCIRCULAITON IN DIABETIC MICROANGIOPATHY AND NEUROPATHY. PATIENTS WITH SEVERE DIABETIC MICROANGIOPAHTY, NEUROPATHY, AND EDEMA; PATIENTS WITH MICROANGIOPATHY WITHOUT NEUOPATHY; AND HEALTHY SUBJECTS WER EINCLUDED. MICROAGNIOPATHY WAS DEFINED BY LASER DOPPLER AND CAPILLARY FILTRAITON (RATE ON SWELLING). INCLUSION CRITERIA WERE INCREASE IN RESTING FLUX AND RAT OF ANKLE SWELLING; DECREASE IN VENOARTERIOLAR RESPONSE (VAR) AND ALTERATION IN FLUX INCREASE WITH TEMPERATURE. PATIENTS WERE RANDOMIZED: THE TREATMENT GROUP RECEIVED TTFCA (TABLETS, 60 MG TWICE DAILY FOR 12 MONTHS); THOSE IN THE PLACEBO GROUP RECEIVED SIMILAR TABLETS. HEALTHY CONTROLS WERE FOLLOWED UP AS A REFENCE. GROUPS WERE COMPARABLE; THERE WERE NO DROPOUTS. THERE WERE NO DIFFERENCES IN THE TREATMENT AND PLACEBO GROUPS AT INCLUSION. TREATMENT WAS WELL TOLERATED; NO SIDE EFFECTS WERE REPORTED. NO VARIATIONS WERE OBSERVED IN NORMALS AT 12 MONTHS. IN THE NEUROPATHY A-GROUP, DECREASES (P<0.05) IN RF AND RAS WERE OBSERVED IN THE TWO TREATMENT GROUPS. THE DECREASE IN RAS WAS ASSOCIATED WITH A DECREASE IN EDEMA (P<0.05) IN BOTH TREATMENT GROUPS. THE DIFFERENCE IN FLUX (38%) AN DIN VAR (38%) WERE ASSOCIATED WIHT A DECREASE (28%) IN THE RATE OF ANKLE SWELLING (P<0.05). IN PATIENTS WITHOUT NEUROPATHY (B-GROUP) THE DECREASE IN FLUX WAS 22%, THE VAR INCREASED 22.7% AND THE RAS DECREASED 9.5% AT 12 MONTHS. |
| Dose amount | 120.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | TRITERPENE FRACTION |
| Gender | GIVEN TO BOTH SEXES |