Experiment 68258
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Centella asiatica (APIACEAE) |
| Citation | CESARONE,MR: BELCARO,G: RULO,A: GRIFFIN,M: RICCI,A: IPPOLITO,E: DE DANCTIS,MT: INCANDELA,L: BAVERA,P: CACCHIO,M: BUCCI,M:. (2001). MICROCIRCULATORY EFFECTS OF TOTAL TRITERPENIC FRACTION OF CENTELLA ASIATICA IN CHRONIC VENOUS HYPTERSION: MEASUREMENT BY LASER DOPPLER, TCPO2-C02, AND LEG VOLUMETRY.. 52(S2) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE AIM OF THIS PROSPECTIVE, RANDOMIZED STUDY WAS TO DEMONSTRATE WHETHER AN ORAL PREPARATION OF TTFCA WAS EFFECTIVE IN IMPROVING THE MICROCIRCULAITON AND EDEMA (LEG VOLUME) IN VENOUS MICROANGIOPATHY. FORTY PATIENTS WITH VENOUS HYPERTENSION WERE INCLUDED. TREATMENT WAS PRESCRIBED FOR 6 WEEKS (TABLETS, 60 MG TWICE DAILY). PATIENTS WERE RANDOMIZED INTO A TREATMENT AND A PLACEBO GROUP. THERE WERE 20 PATIENTS IN EACH GROUP. IN THE TREATMENT GROUP THE MEAN AGE WAS 42 (SD 7; M:F=10:10); IN THE PLACEBO GROUP, THE MEAN AGE WAS 40 (SD 9; M:F=10:10). TOLERABILITY AND COMPLAINCE WERE VERY GOOD; THERE WERE NO DROPOUTS. AT INCLUSION THERE WERE NO DIFFERENCES BETWEEN PLACEBO AND TREATMENT GROUP. AFTER TREATMENT THERE WAS A DECREASE IN RESTING FLUX (29%) AND AN IMPROVEMENT (INCREASE) IN VENOARTERIOLAR RESPONSE (52%); PO2 WAS INCREASED (7.2%) AND PCO2 DECREASED (9.6%). THERE WAS AN IMPORTANT DECREASE IN LEG VOLUME (66 ML DECREASE; 1.3% VOLUME VARIATION). THE DIFFERENCE IN FLUX, 02-CO2 AND VOLUME PARAMETERS WERE SIGNIFICANT AND CLINICALLY IMPORTANT AT 6 WEEKS IN THE TREATMENT GROUP. IN CONCLUSION, TTFCA IMPROVES MICROCIRCULAITON AND LEG VOLUME IN VENOUS HYPERTENSION. THE EFFECTS OF TTFCA ARE OBSERVED EVEN IN A LIMITED SAMPLE OF PATIENTS. |
| Dose amount | 120.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | TRITERPENE FRACTION |