Experiment 68314
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Uncaria tomentosa (RUBIACEAE) |
| Citation | PISCOYA,J: RODRIGUESZ,Z: BUSTAMANTE,SA: OKUHAMA,NN: MILLER,MJS: SANDOVAL,M:. (2001). EFFICACY AND SAFETY OF FREEZE-DRIED CAT'S CLAW IN OSTEOARTHRITIS OF THE KNEE: MECHANISMS OF ACTION OF THE SPECIES UNCARIA GUIANENSIS.. 50(9) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE PURROSE OF THIS INVESTIGATION WAS TO EVALUATE THE ABILITY OF CAT'S CLAW, AN AMOZONIAN MEDICINAL PLANT, TO TREAT OSTEOARTHRITIS OF THE KNEE, COLLECT SAFETY AND TOLERANCE INFORMATION AND COMPARE THE ANTIOXIDANT, AND ANTI-INFLAMMATORY ACTIONS OF UNCARIA GUIANENSIS AND UNCARIA TOMENTOSA IN VITRO. FORTY-FIVE PATIENTS WITH OSTEOARTHRITIS OF THE KNEE WERE RECRUITED, 30 WERE TREATED WITH FREEZE-DRIED U. GUIANENSIS, AND 15 WITH PLACEBO. CAT'S CLAW IS AN EFFECTIVE TREATMENT FOR OSTEOARTHRITIS. THE SPECIES, U.GUIANENSIS AND U.TOMENTOSA ARE EQUIACTIVE. THEY ARE EFFECTIVE ANTIOXIDANTS, BUT THEIR ANTI-INFLAMMATORY PROPERTIES MAY RESULT FROM THEIR ABILITY TO INHIBIT TNFALPHA AND TO A LESSER EXTENT PGE2 PRODUCTION. |
| Dose amount | 100.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | LYOPHILIZED EXTRACT |
| Gender | MALE |