Experiment 68326
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Nasturtium officinale (BRASSICACEAE) |
| Citation | MURPHY,SE:. (2001). CONSUMPTION OF WATERCRESS FAILS TO ALTER COUMARIN METABOLISM IN HUMANS.. 29(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | THIS STUDY INVESTIGATED THE EFFECT OF WATERCRESS CONSUMPTION ON COUMARIN 7-HYDROXYLATION, A P450 2A6 SPECIFIC REACTION, IN A GROUP OF 15 NONSMOKING, HEALTHY VOLUNTEERS. THE URINARY EXCRETION OF 7-HYDROXYCOUMARIN (7OHC) WAS DETERMINED. FOR 6 OF THE 15 SUBJECTS, WATERCRESS CONSUMPTION DECREASED THE AMOUNT OF 7 OHC EXCRETED IN THE FIRST 2 H FOLLOWING COUMARIN ADMINISTRATION. HOWEVER, THE MEAN 0- TO 2-H EXCRETION OF 7 OHC FOR ALL 15 SUBJECTS WAS NOT SIGNIFICANTLY LOWERED BY THE CONSUMPTION OF WATERCRESS, 2.8 + 0.78 VERSUS 3.1 + 0.53 MG (+S.D.). THE MEAN 7OHC EXCRETED FROM 2 TO 4 H (1.1 + 0.50 MG) WAS SIGNIFICANTLY HIGHER (P=0.027) DURING WATERCRESS CONSUMPTION THAN BEFORE (0.77 + 0.22 MG), SUGGESTING A DELAY IN COUMARIN METABOLISM. TOTAL EXCRETION OF 7OHC WAS UNAFFECTED BY WATERCRESS CONSUMPTION. THEREFORE, UNDER THE CONDITIONS OF OUR STUDY, PEITC AND OTHER CONSTITUENTS OF WATERCRESS HAD AT MOST A MARGINAL INHIBITORY EFFECT ON P450 2A6-CATALYZED COUMARIN 7-HYDROXYLATION. |
| Dose amount | 13.6 GM |
| Number | 2 |
| Qualitative result | . |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | IC100 |
| Extract | AERIAL PARTS |
| Gender | GIVEN TO BOTH SEXES |