Experiment 68327
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | JACOBSON,JM: FEINMAN,L: LIEBES,L: OSTROW,N: KOSLOWSKI,V: TOBIA,A: CABANA,BE: LEE,GH: SPRITZLER,J: PRINCE,AM:. (2001). PHARMACOKINETICS, SAFETY, AND ANTIVIRAL EFFECTS OF HYPERICIN, A DERIVATIVE OF ST. JOHN'W WORT PLANT, IN PATIENTS WITH CHRONIC HEPATITIS C VIRUS INFECTION.. 45(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | WE CONDUCTED A PHASE I DOSE ESCALATION STUDY TO DETERMINE THE SAFETY AND ANTIVIRAL ACTIVITY OF HYPERICIN IN PATIENTS WITH CHRONIC HCV INFECTION. THE FIRST 12 PATIENTS RECEIVED AN 8-WEEK COURSE OF 0.05 MG OF HYPERICIN PER KG OF BODY WEIGHT ORALLY ONCE A DAY; 7 PATIENTS RECEIVED AN 8-WEEK COURSE OF 0.10 MG/KG ORALLY ONCE A DAY. AT THE END OF THE 8-WEEK PERIOD OF TREATMENT, NO SUBJECT HAD A CHANGE OF PLASMA HCV RNA LEVEL OF MORE THAN 1.01 LOG10. FIVE OF 12 SUBJECTS RECEIVING THE 0.05- MG/KG/DAY DOSING SCHEDULE AND 6 OF 7 SUBJECTS RECEIVING THE 0.10 MG/KG/DAY DOSING SCHEDULE DEVELOPED PHOTOTOXIC REACTIONS. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |