Experiment 68346
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Petasites hybridus (ASTERACEAE) |
| Citation | SCHAPOWAL,A:. (2002). RANDOMISED CONTROLLED TRIAL OF BUTTERBUR AND CETIRIZINE FOR TREATING SEASONAL ALLERGIC RHINITIS.. 324() |
| Amount utilized | |
| Compound isolated | |
| Disease | TO COMPARE THE EFFICACY AND TOLERABILITY OF BUTTERBUR (PETASITES HYBRIDUS) WITH CETIRIZINE IN PATIENTS WITH SEASONAL ALLERGIC RHINITIS (HAY FEVER). RANDOMISED, DOUBLE BLIND, PARALLEL GROUP COMPARISONS WERE MADE IN FOUR OUTPATIENT GENERAL MEDICINE AND ALLERGY CLINICS IN SWITZERLAND AND GERMANY. 131 PATIENTS WERE SCREENED FOR SEASONAL ALLERGIC RHINITIS AND 125 PATIENTS WERE RANDOMISED (BUTTERBUR 61; CETIRIZINE 64). BUTTERBUR (CARBON DIOXIDE EXTRACT TABLETS, ZE 339) ONE TABLET, FOUR TIMES DAILY, OR CETIRIZINE, ONE TABLET IN THE EVENING, BOTH GIVEN FOR TWO CONSECUTIVE WEEKS. BOTH TREATMENTS WERE WELL TOLERATED. IN THE CETIRIZINE GROUP, TWO THIRDS (8/12) OF REPORTED ADVERSE EVENTS WERE ASSOCIATED WITH SEDATIVE EFFECTS (DROWSINESS AND FATIGUE) DESPITE THE DRUG BEING CONSIDERED A NON-SEDATING ANTIHISTAMINE. THE EFFECTS OF BUTTERBUR ARE SIMILAR TO THOSE OF CETIRIZINE IN PATIENTS WITH SEASONAL ALLERGIC RHINITIS WHEN EVALUATED BLINDLY BY PATIENTS AND DOCTORS. BUTTERBUR SHOULD BE CONSIDERED FOR TREATING SEASONAL ALLERGIC RHINITIS WHEN THE SEDATIVE EFFECTS OF ANTIHISTAMINES NEED TO BE AVOIDED. |
| Dose amount | 32.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | CO2 EXTRACT |
| Gender | GIVEN TO BOTH SEXES |