Experiment 68351
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | GOLDFARB,DS: ASPLIN,JR:. (2001). EFFECT OF GRAPEFRUIT JUICE ON URINARY LITHOGENICITY.. 166(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | AN INCREASED RISK OF NEPHROLITHIASIS HAS BEEN ASSOCIATED WITH THE INGESTION OF GRAPEFRUIT JUICE IN EPIDEMIOLOGICAL STUDIES. WE STUDIED THE EFFECT OF GRAPEFRUIT JUCIE CONSUMPTION ON URINARY CHEMISTY AND MEASURES OF LITHOGENICITY. TEN HEALTHY MEN AND WOMEN BETWEEN AGES OF 25 AND 40 YEARS PARTICIPATED. EACH SUBJECT DRANK 240 ML. OF TAP WATER AT LEAST 3 TIMES DAILY FOR 7 DAYS DRING THE CONTROL PERIOD. THIS PERIOD WAS FOLLOWED BY A SECOND 7 DAYS EXPERIMENTAL PERIOD DURING WHICH THEY DRANK 240 ML. OF GRAPEFRUIT JUICE 3 TIMES DAILY. IN EACH 7-DAY PERIOD URINE WAS COLLECTED FOR 24 HOURS DURING THE LAST 3 DAYS. URINE CHEMICAL ANALYSIS WAS PERFORMED, SUPERSATURATIONS OF CALCIUM OXALATE, CALCIUM PHOSPHATE AND RUIC ACID WERE CALCULATED AND RUINARY LITHOGENICITY WAS MEASURED. OFFSETTING CHANGES IN URINE CHEMISTRY CAUSED BY THE INGESTION OF GRAPEFRUIT JUICE LED TO NO NET CHANGE IN CALCULATED SUPERSATURATION. NO CHANGES IN LITHOGENICITY WERE DEMONSTRATED. THE RESULTS DO NOT DEMONSTRATE AN EFFECT OF GRAPEFRUIT JUICE FOR INCREASING LITHOGERICITY. THE BASIS OF THE OBSERVATIONS OF EPIDEMIOLOGICAL STUDIES REMAIN UNEXPLAINED. |
| Dose amount | 720.0 ML |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | JUICE |
| Gender | GIVEN TO BOTH SEXES |