Experiment 68509

Worktypes

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismVaccinium macrocarpon (ERICACEAE)
CitationTERRIS,MK: ISSA,MM: RACKER,JR:. (2001). DIETARY SUPPLEMENTATION WITH CRANBERRY CONCENTRATE TABLETS MAY INCREASE THE RISK OF NEPHROLITHIASIS.. 57(1)
Amount utilized
Compound isolated
DiseaseFIVE HEALTHY VOLUNTEERS ON A NORMAL DIET PROVIDED 24-HOUR URINE COLLECTION FOR PH, VOLUME, CREATININE, OXALATE, CALCIUM, PHOSPHATE, URIC ACID, SODIUM, CITRATE, MAGNESIUM, AND POTASSIUM. CRANBERRY TABLETS WERE ADMINISTERED TO THESE VOLUNTEERS AT THE MANUFACTURER'S RECOMMENDED DOSAGE FOR 7 DAYS. ON THE SEVENTH DAY, A SECOND 24-HOUR URINE COLLECTION WAS OBTAINED. THE URINARY OXALATE LEVELS IN THE VOLUNTEERS SIGNIFICANTLY INCREASED (P=O.01) BY AN AVERAGE OF 43.4% WHILE RECEIVING CRANBERRY TABLETS. THE EXCRETION OF POTENTIAL LITHOGENIC IONS CALCIUM, PHOSPHATE, AND SODIUM ALSO INCREASED. HOWEVER, INHIBITORS OF STONE FORMATION, MAGNESIUM AND POTASSIUM, ROSE AS WELL. CRANBERRY CONCENTRATE TABLETS ARE MARKETED FOR URINARY TRACT AILMENTS. PHYSICIANS AND MANUFACTURER OF CRANBERRY PRODUCTS SHOULD MAKE AN EFFORT TO EDUCATE PATIENTS AT RISK FOR NEPHROLITHIASIS AGAINST INGESTION OF THESE DIETARY SUPPLEMENTS.
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Dose expressionDOSE
ExtractFRUIT
GenderGIVEN TO BOTH SEXES