Experiment 68549
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Aesculus hippocastanum (HIPPOCASTANACEAE) |
| Citation | LOEW,D: SCHRODTER,A: SCHWANKL,W: MARZ,RW:. (2000). MEASUREMENT OF THE BIOAVAILABILITY OF AESCIN-CONTAINING EXTRACTS.. 227() |
| Amount utilized | |
| Compound isolated | |
| Disease | IN HORSE CHESTNUT SEED EXTRACTS (HCSE), THE TRITERPENE SAPONIN MIXTURE AESCIN IS CONSIDERED THE ACTIVE PRINCIPLE. THE BIOAVAILABILITY AND PHARMACOKINETICS OF DIFFERENT HCSE PREPARATIONS HAVE BEEN STUDIED UNDER SINGLE AND REPEATED APPLICATIONS USING A RADIOMMUNOLOGICAL METHOD (RIA) DEVELOPED TO IDENTIFY BETA-AESCIN, ONE OF THE PHARMACOLOGICALLY ACTIVE FRACTIONS OF THE SAPONIN MIXTURE. PHARMACOKINETIC DATA FROM 5 SINGLE-AND 4 MULTIPLE-DOSE BIOEQUIVALENCE STUDIES WITH HCES-CONTAINING PRODUCTS, WERE MEASURED BY THE SAME ANALYTICAL LABORATORY USING THE SAM RIA. IN STUDIES WHERE PROCEDURES WERE IDENTICAL THE PHARMACOKINETIC DATA OF BETA-AESCIN SHOW HIGH VARIATIONS. EVEN UNDER STEADY-STATE CONDITIONS A CONSIDERABLE VARIABILITY FOR THE SAM HCSE PRODUCT IS OBTAINED. FORMAL REASONS LIKE STUDY DESIGN AND MEDICATIONS CAN BE RULED OUT AS A SOURCE OF PHARMACOKINETIC VARIATION. IN EXTRACTS OF HERBAL DURGS LIKE HCS, THE RELATIVE CONCENTRATION OF THE INDIVIDUAL SAPONIN FRACTIONS CAN CONSIDERABLY DIFFER FROM BATCH TO BATCH. |
| Dose amount | 100.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | TYPE EXT NOT STATED |
| Gender | MALE |