Experiment 68664
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | BECQUEMONT,L: VERSTUYFT,C: KERB,R: BRINKMANN,U: LEBOT,M: JAILLON,P: CFUNCK-BRENTANO,C:. (2001). EFFECT OF GRAPEFRUIT JUICE ON DIGOXIN PHARMACOKINETICS IN HUMANS.. 7(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | TWELVE HEALTHY VOLUNTEERS PARTICIPATED IN THIS OPEN RANDOMIZED CROSSOVER STUDY COMPARING THE EFFECT OF GRAPEFRUIT JUICE CONSUMPTION (VERUS WATER) ON THE PHARMACOKINETICS OF A SINGLE ORAL DOSE OF DIGOXIN (0.5 MG). THE P-GLYCOPROTEIN GENOTYPE WAS DETERMINED ACCORDING TO MDR1 GENETIC POLYMORPHISM IN EXON 26 (C3435T). GRAPEFRUIT JUICE HAD NO EFFECT ON PLASM CONCENTRATIONS. THE MODEST CHANGES IN DIGOXIN PHARMACOKINETICS OBSERVED DURING GRAPEFRUIT JUICE INGESTION DO NOT SUPPORT AN IMPORTANT P-GLYCOPROTEIN INHIBITION. UNDER OUR EXPERIMENTAL CONDITIONS, GRAPEFRUIT JUICE-MEDIATED P-GLYCOPROTEIN INHIBITION DOES NOT APPEAR TO PLAY A RELEVANT ROLE IN DRUG INTERACTIONS, AT LEAST WHEN ASSESSED BY USE OF DIGOXIN DISPOSITION KINETICS. |
| Dose amount | 220.0 ML |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | JUICE |
| Gender | GIVEN TO BOTH SEXES |