| Disease | TO ASSESS THE EFECTS IN HUMANS OF REGULAR INGESTION OF BLACK TEA ON HAEMOSTASIS-RELATED VARIABLES AND CELL ADHESION MOLECULES IN 22 SUBJECTS. TWENTY-TWO SUBJECTS WERE RECRUITED FROM THE GENERAL POPULATION TO A RANDOMISED-CONTROLLED CROSSOVER
STUDY. SUBJECTS STOPPED DRINKING TEA, APART FROM THAT PROVIDED, FOR THE DURATION OF THE STUDY. DURING A 4-WEEK BASELINE PERIOD ALL SUBJECTS DRANK 5 CUPS/DAY (250ML) OF HOT WATER. THE EFFECTS OF 5 CUPS/DAY OF BLACK TEA FOR 4 WEEKS WERE THEN
COMPARED WITH HOT WATER. PLATELET AGGREGATION IN RESPONSE TO THREE DOSES OF COLLAGEN AND ADP, PLASMA CONCENTRATIONS OF COAGULATION AND FIBRINOLYTIC FACTORS (FIBRINOGEN, FACTOR VII, TPA, PAI-1) AND PLASMA CONCENTRATION OF CELL ADHESION MOLECULES
(SOULBLE P-SELECTIN, E-SELECTIN, ICAM-1, VCAM-1) WERE ASSESSED TWICE, ONE WEEK APART, AT THE END OF EACH PERIOD. TWENTY-FOUR HOUR URINARY CONCENTRATION OF 4-O-METHYLGALLIC ACID (40MGA), ASSESSED ONCE AT THE END OF EACH PERIOD, WAS USED AS A
MARKER OF BLACK TEA POLYPHENOL INTAKE. THE 24 H URINARY EXCRETION OF 40MGA WAS INCREASED DURING REGULAR INGESTION OF BLACK TEA IN COMPARISON OF HOT WATER (P<0.0001). BLACK TEA RESULTED IN LOWER SOLUBLE P-SELECTION (P=0.01) IN COMPARISON TO
HOT WATER, BUT DID NOT INFLUENCE OTHER ADHESION MOLECULES. CONAGULATION AND FIBINOLYTIC FACTORS WERE NOT DIFFERENT BETWEEN PERIODS. THE EFFECT OF BLACK TEA ON SOLUBLE P-SELECTIN PROVIDE A MECHANISM FOR CARDIOVASCULAR BENEFITS OF REGULAR
INGESTION OF TEA. |