Experiment 68692
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | FRANKLIN,M: COWEN,PJ:. (2001). RESEARCHING THE ANTIDPRESSANT ACTIONS OF HYPERICUM PERFORATUM (ST. JOHN'S WORT) IN ANIMALS AND MAN.. 34(S1) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN ACUTE TREATMENT STUDIES IN NORMAL VOLUNTEERS SUBJECTS RECEIVED 9 TABLETS OF THE FINISHED PRODUCT JARSIN 300 AND PLACEBO IN THE PILOT STUDY (UMBLINDED) AND IN THE MAIN STUDY ( A DOUBLE BLIND, BALANCED ORDER, CROSS-OVER DESIGN). RESULTS IN NORMAL VOLUNTEER STUDIES SHOW THAT HP CAUSED SIGNIFICANT INCREASES OF SALIVARY CORTISOL AND PLASMA GROWTH HORMONE (GH) WHEREAS IT DECREASED PLASMA PROLACTIN VERSUS PLACEBO. PLASMA HORMONE LEVELS WERE ASSOCIATED WITH A RISE IN PLASMA HYPERFORIN BUT NOT WITH HYPERICIN, HOWEVER NO SIGNIFICANT CORRELATION WAS FOUND. |
| Dose amount | 900.0 MG |
| Number | 3 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | MALE |