Experiment 68698
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | SETNIKAR,I: ROVATI,LC:. (2001). ABSORPTION, DISTRIBUTION, METABLISM AND EXCRETION OF GLUCOSAMINE SULFATE.. 51(9) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN MAN, AFTER SINGLE DOSE OF 7.5 G. CGS, GI IN PLAMS WAS BELOW THE LIMIT OF QUANTITATION (3 UG/ML) OF THE ION EXCHANGE CHROMATOGRAPHY METHOD. AFTER A SINGLE DOSE OF 314 MG CGS TRACED WITH 14C-GI, RADIOACTIVITY APPEARED INCORPORATED IN PLASMA GLOBULINS WITH A LAG TIME OF 1.5 H AND INCREASING WITH A RATE OF 0.24 H-1. THE PEAK WAS REACHED AT THE 9TH H AFTER ADMINISTRATION. THE RADIOACTIVITY THEN WAS ELIMINATED WITH T1/2 OF 58 H. THE ABSOLUTE ORAL BIOAVAILABILITY EVALUATED ON THE AUCS OF THE GLOBULIN-INCORPORATED RADIOACTIVITY WAS 44%. THE FECAL EXCRETION IN 120 H WAS 11.3% OF THE ADMINISTERED DOSE SHOWING THAT AT LEAST 88.7% OF THE ADMINISTERED DOSE WWA ABSORBED THROUGH THE GASTRIOINTESTINAL TRACT. THE DIFFERENCE OF 45% IS PROBABALY DUE TO A HEPATIC FIRST-PASS EFFECT. THE URINARY ELIMINATION IN MAN OF THE PARENT GI IN 24 H DETERMINED WITH ION EXCHANGE CHROMATOGRAPHY AFTER A SINGLE DOSE OF 7.5 OF GCS WAS 1.19% OF THE ADMINISTERED DOSE. |
| Dose amount | 7.5 GM |
| Number | 4 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |