Experiment 68742
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | NI,Z: MU,Y: GULATI,O:. (2002). TREATMENT OF MELASMA WITH PYCNOGENOL.. 16(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | THIRTY WOMEN WITH MELASMA COMPLETED A 30-DAY CLINICAL TRIAL IN WHICH THEY TOOK ONE 25 MG TABLET OF PYCNOGENOL WITH MEALS THREE TIMES DAILY, I.E. 75 MG PYCNOGENOL PER DAY. THESE PATIENTS WERE EVALUATED CLINICALLY BY PARAMETER SUCH AS THE MELASMA AREA INDEX, PIGMENTARY INTENSITY INDEX AND BY ROUTINE BLOOD AND URINE TESTS. AFTER A 30-DAY TREATMENT, THE AVERAGE MELASMA AREA OF THE PATIENTS DECREASED BY 25.86+20.39 MM (P<0.001) AND THE AVERAGE PIGMENTARY INTENSITY DECREASED BY 0.47+0.51 UNIT (P<0.001). THE GENERAL EFFECTIVE RATE WAS 80%. NO SIDE EFFECT WAS OBSERVED. THE RESULTS OF THE BLOOD AND URING TEST PARAMETERS AT BASELIND AND DAY 30 WERE WITHIN THE NORMAL RANGE. MOREOVER, SEVERAL OTHER ASSOCIATED SYMPTOMS SUCH AS FATIGUE, CONSTIPATION, PAINS IN THE BODY AND ANXIETY WERE ALSO IMPROVED. TO CONLUDE, PYCOOGENOL WAS SHOWN TO BE THERAPEUTICALLY EFFECTIVE AND SAFE IN PATIENTS SUFFERING FROM MELASMA. |
| Dose amount | 75.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | TYPE EXT NOT STATED |
| Gender | FEMALE |